Medical Department, Sarawak General Hospital (SGH), Kuching, Malaysia.
Faculty of Medicine and Health Sciences, University Malaysia Sarawak (UNIMAS), Jalan Datuk Mohammad Musa, 94300, Kota Samarahan, Sarawak, Malaysia.
BMC Cardiovasc Disord. 2020 Dec 7;20(1):511. doi: 10.1186/s12872-020-01793-7.
Data on clinical characteristics of acute decompensated heart failure (ADHF) in Malaysia especially in East Malaysia is lacking.
This is a prospective observational study in Sarawak General Hospital, Medical Department, from October 2017 to September 2018. Patients with primary admission diagnosis of ADHF were recruited and followed up for 90 days. Data on patient's characteristics, precipitating factors, medications and short-term clinical outcomes were recorded.
Majority of the patients were classified in lower socioeconomic group and the mean age was 59 years old. Hypertension, diabetes mellitus and dyslipidaemia were the common underlying comorbidities. Heart failure with ischemic aetiology was the commonest ADHF admission precipitating factor. 48.6% of patients were having preserved ejection fraction HF and the median NT-ProBNP level was 4230 pg/mL. Prescription rate of the evidence-based heart failure medication was low. The in-patient mortality and the average length of hospital stay were 7.5% and 5 days respectively. 43% of patients required either ICU care or advanced cardiopulmonary support. The 30-day, 90-day mortality and readmission rate were 13.1%, 11.2%, 16.8% and 14% respectively.
Comparing with the HF data from West and Asia Pacific, the short-term mortality and readmission rate were high among the ADHF patients in our study cohort. Maladaptation to evidence-based HF prescription and the higher prevalence of cardiovascular risk factors in younger patients were among the possible issues to be addressed to improve the HF outcome in regions with similar socioeconomic background.
马来西亚,尤其是东马来西亚,缺乏关于急性失代偿性心力衰竭(ADHF)临床特征的数据。
这是 2017 年 10 月至 2018 年 9 月在砂拉越总医院内科进行的一项前瞻性观察研究。招募了以 ADHF 为主要入院诊断的患者,并对其进行了 90 天的随访。记录了患者的特征、诱发因素、药物治疗和短期临床结局的数据。
大多数患者来自较低社会经济群体,平均年龄为 59 岁。高血压、糖尿病和血脂异常是常见的合并症。心力衰竭的缺血性病因是最常见的 ADHF 入院诱发因素。48.6%的患者射血分数保持正常,中位 NT-ProBNP 水平为 4230pg/ml。基于证据的心力衰竭药物的处方率较低。住院死亡率和平均住院天数分别为 7.5%和 5 天。43%的患者需要重症监护或高级心肺支持。30 天、90 天死亡率和再入院率分别为 13.1%、11.2%、16.8%和 14%。
与西方和亚太地区的心力衰竭数据相比,我们研究队列中的 ADHF 患者短期死亡率和再入院率较高。在社会经济背景相似的地区,可能需要解决适应基于证据的心力衰竭处方和年轻患者心血管风险因素高发的问题,以改善心力衰竭结局。