Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
Anticancer Res. 2020 Dec;40(12):7031-7035. doi: 10.21873/anticanres.14729. Epub 2020 Dec 7.
Innominate grooves (IGs) in the colon are ubiquitous structures limiting anthemic folds. The histology of the crypts in anthemic folds is well known but the histology of IGs has remained unattended. In this study, IG crypts in the normal mucosa and in ulcerative colitis (UC) were analyzed.
IGs displayed a single central-lumen with merging tributary crypts. The number of merging tributary crypts, at both sides and at the bottom of the central lumen, were quantified in 60 IGs: 30 in normal colons and 30 in UC.
A total of 152 (median=5) tributary crypts were found merging in the 30 IGs in the normal colon, and 170 (median=5) in the 30 IGs in UC. The difference was non-significant (p=0.08012).
Chronic inflammation did not influence the frequency of tributary crypts in IGs. The shape and the length varied considerably in the 60 IGs. Given that the chief putative physiological function of IGs is the expansion of the colon when submitted to increased intraluminal pressure, it is not inconceivable that following that demand, IGs act as hinges that permit grooves to level with the rest of the surrounding mucosa.
结肠无名沟（IG）是普遍存在的结构，限制了结肠袢的展开。展开袢的隐窝组织学已广为人知，但 IG 的组织学尚未得到关注。本研究分析了正常黏膜和溃疡性结肠炎（UC）中的 IG 隐窝。
IG 显示单一中央腔，合并有支流隐窝。在 60 个 IG 中，分别对中央腔两侧和底部的合并支流隐窝数量进行了量化：30 个在正常结肠中，30 个在 UC 中。
在 30 个正常结肠 IG 中，共发现 152 个（中位数=5）支流隐窝合并，在 30 个 UC IG 中，共发现 170 个（中位数=5）支流隐窝合并。差异无统计学意义（p=0.08012）。
慢性炎症并未影响 IG 中支流隐窝的频率。在 60 个 IG 中，其形状和长度变化很大。鉴于 IG 的主要假定生理功能是在受到增加的腔内压力时扩张结肠，因此不难想象，为了满足这一需求，IG 充当铰链，使沟与周围其余黏膜平齐。
