大麻素对神经源性炎症的调控。
Cannabinoid control of neurogenic inflammation.
机构信息
Departments of Pharmacology and Anaesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
出版信息
Br J Pharmacol. 2020 Oct;177(19):4386-4399. doi: 10.1111/bph.15208. Epub 2020 Aug 13.
Abstract
A significant number of cannabinoids are known to have analgesic and anti-inflammatory properties in various diseases. Due to their presynaptic/terminal location, cannabinoid receptors can inhibit synaptic transmission and have the potential to regulate neurogenic inflammation. Neurogenic inflammation occurs when a noxious signal is detected in the periphery initiating an antidromic axon reflex in the same sensory neurone leading to depolarization of the afferent terminal. Neuropeptides are subsequently released and contribute to vasodilation, plasma extravasation and modulation of immune cells. Endocannabinoids, synthetic cannabinoids and phytocannabinoids can reduce neuroinflammation by inhibiting afferent firing and inflammatory neuropeptide release. Thus, in addition to a direct effect on vascular smooth muscle and inflammatory cells, cannabinoids can reduce inflammation by silencing small diameter neurones. This review examines the neuropharmacological processes involved in regulating antidromic depolarization of afferent nerve terminals by cannabinoids and the control of neurogenic inflammation in different diseases.
摘要
已知大量大麻素具有在各种疾病中的镇痛和抗炎特性。由于它们位于突触前/末端位置，大麻素受体可以抑制突触传递，并且有可能调节神经原性炎症。当在外周检测到有害信号时，会发生神经原性炎症，从而引发同一感觉神经元中的逆行轴突反射，导致传入末端去极化。随后释放神经肽并有助于血管扩张、血浆渗出和免疫细胞的调节。内源性大麻素、合成大麻素和植物大麻素可以通过抑制传入放电和炎症神经肽的释放来减少神经炎症。因此，除了对血管平滑肌和炎症细胞的直接影响外，大麻素还可以通过沉默小直径神经元来减少炎症。本综述检查了大麻素调节传入神经末梢逆行去极化的神经药理学过程，以及在不同疾病中对神经原性炎症的控制。
相似文献
1
Cannabinoid control of neurogenic inflammation.大麻素对神经源性炎症的调控。
Br J Pharmacol. 2020 Oct;177(19):4386-4399. doi: 10.1111/bph.15208. Epub 2020 Aug 13.
2
Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization.脊髓孤啡肽受体-1的激活可预防急性皮肤神经源性炎症：痛敏肽诱导的初级传入去极化抑制作用
Pain. 2002 Apr;96(3):309-318. doi: 10.1016/S0304-3959(01)00460-2.
3
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy.内源性大麻素与疼痛：炎症和神经病变中的脊髓和外周镇痛作用
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):243-56. doi: 10.1054/plef.2001.0362.
4
Endocannabinoids inhibit neurogenic inflammation in murine joints by a non-canonical cannabinoid receptor mechanism.内源性大麻素通过非经典大麻素受体机制抑制鼠关节的神经原性炎症。
Neuropeptides. 2017 Aug;64:131-135. doi: 10.1016/j.npep.2016.08.007. Epub 2016 Aug 22.
5
Phytocannabinoids and endocannabinoids.植物大麻素和内源性大麻素。
Curr Drug Abuse Rev. 2009 Jan;2(1):51-75. doi: 10.2174/1874473710902010051.
6
Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation.单酰甘油脂肪酶通过内源性大麻素在持续炎症后保护突触前大麻素 1 受体脱敏。
J Neurosci. 2023 Jul 26;43(30):5458-5467. doi: 10.1523/JNEUROSCI.0037-23.2023. Epub 2023 Jul 6.
7
Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function.大麻素通过大麻素受体和香草酸受体对感觉神经传递的调节：在心血管功能调节中的作用
Life Sci. 2002 Oct 18;71(22):2577-94. doi: 10.1016/s0024-3205(02)02086-6.
8
Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation.感觉传入纤维和神经原性炎症中的逆行性活动的起源。
Semin Immunopathol. 2018 May;40(3):237-247. doi: 10.1007/s00281-017-0669-2. Epub 2018 Feb 8.
9
Interplay between cannabinoids and the neuroimmune system in migraine.大麻素与偏头痛中神经免疫的相互作用。
J Headache Pain. 2024 Oct 16;25(1):178. doi: 10.1186/s10194-024-01883-3.
10
Cannabinoids, endocannabinoids, and related analogs in inflammation.炎症中的大麻素、内源性大麻素及相关类似物。
AAPS J. 2009 Mar;11(1):109-19. doi: 10.1208/s12248-009-9084-5. Epub 2009 Feb 6.
引用本文的文献
1
Neural Signatures of Cannabis Use: Reversing Cognitive Aging via Whole-Brain Functional Network Connectivity.大麻使用的神经特征：通过全脑功能网络连接逆转认知衰老
Res Sq. 2025 Aug 1:rs.3.rs-6977015. doi: 10.21203/rs.3.rs-6977015/v1.
2
Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats.在雄性斯普拉格-道利大鼠单次口服给药后，将微粉化和水分散性棕榈酰乙醇胺与标准棕榈酰乙醇胺的药代动力学进行比较。
Indian J Pharmacol. 2025 Jul 1;57(4):219-225. doi: 10.4103/ijp.ijp_964_24. Epub 2025 Jul 21.
3
Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches.揭示植物大麻素的分子靶点：反向分子对接指纹方法的机制洞察
Front Pharmacol. 2025 Jun 27;16:1611461. doi: 10.3389/fphar.2025.1611461. eCollection 2025.
4
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus.重复合成大麻素暴露和戒断对前额叶皮层和海马体内内源性大麻素信号传导、神经胶质增生和炎症标志物的区域特异性影响。
Biomolecules. 2025 Mar 14;15(3):417. doi: 10.3390/biom15030417.
5
CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide.全身应用硝酸甘油后大鼠尾侧三叉神经核中钙/钙调蛋白依赖性蛋白激酶IIα（CamKIIα）和血管活性肠肽1型受体（VPAC1）的表达：与花生四烯酸乙醇胺的相互作用
Life (Basel). 2025 Jan 22;15(2):155. doi: 10.3390/life15020155.
6
Interplay between cannabinoids and the neuroimmune system in migraine.大麻素与偏头痛中神经免疫的相互作用。
J Headache Pain. 2024 Oct 16;25(1):178. doi: 10.1186/s10194-024-01883-3.
7
Anti-Inflammatory Properties of Cannabidiol and Beta-Caryophyllene Alone or Combined in an In Vitro Inflammation Model.大麻二酚和β-石竹烯单独或联合在体外炎症模型中的抗炎特性
Pharmaceuticals (Basel). 2024 Apr 7;17(4):467. doi: 10.3390/ph17040467.
8
Heteromers Formed by GPR55 and Either Cannabinoid CB or CB Receptors Are Upregulated in the Prefrontal Cortex of Multiple Sclerosis Patients.由GPR55与大麻素CB1或CB2受体形成的异聚体在多发性硬化症患者前额叶皮质中上调。
Int J Mol Sci. 2024 Apr 10;25(8):4176. doi: 10.3390/ijms25084176.
9
Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models.甘草素通过调节 LPS 诱导的体外和体内模型中的炎症信号来减轻神经炎症。
Inflammopharmacology. 2024 Apr;32(2):1159-1169. doi: 10.1007/s10787-023-01424-5. Epub 2024 Feb 19.
10
Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications.急性胰腺炎疼痛的分子机制：近期基础研究进展及治疗意义
Front Mol Neurosci. 2023 Dec 22;16:1331438. doi: 10.3389/fnmol.2023.1331438. eCollection 2023.
本文引用的文献
1
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception.花生四烯酸衍生的前列腺素对外周伤害性感受作用的分子机制。
J Neuroinflammation. 2020 Jan 22;17(1):30. doi: 10.1186/s12974-020-1703-1.
2
Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis.通过在骨关节炎大鼠模型中双重抑制单酰基甘油脂肪酶和环氧化酶-2来治疗关节疼痛和炎症。
Arthritis Res Ther. 2020 Jan 14;22(1):9. doi: 10.1186/s13075-020-2096-3.
3
Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity.棕榈酰乙醇酰胺通过刺激二酰基甘油脂肪酶活性来拮抗 P 物质诱导的体外肥大细胞活化。
J Neuroinflammation. 2019 Dec 26;16(1):274. doi: 10.1186/s12974-019-1671-5.
4
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.2019/20 年药理学简明指南：G 蛋白偶联受体。
Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748.
5
n-3 polyunsaturated N-acylethanolamines are CB cannabinoid receptor-preferring endocannabinoids.n-3 多不饱和 N-酰基乙醇胺是 CB 大麻素受体优先的内源性大麻素。
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov;1863(11):1433-1440. doi: 10.1016/j.bbalip.2018.08.003. Epub 2018 Aug 7.
6
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.大麻素受体和内源性大麻素系统：中枢神经系统中的信号传递和功能。
Int J Mol Sci. 2018 Mar 13;19(3):833. doi: 10.3390/ijms19030833.
7
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.2018 年 IUPHAR/BPS 药理学指南：更新和扩展，以包含新的免疫药理学指南。
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. doi: 10.1093/nar/gkx1121.
8
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.大麻二酚减轻早期炎症反应，预防大鼠骨关节炎疼痛和神经损伤。
Pain. 2017 Dec;158(12):2442-2451. doi: 10.1097/j.pain.0000000000001052.
9
Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads.大麻药理学：常见因素与一些有前景的线索
Adv Pharmacol. 2017;80:67-134. doi: 10.1016/bs.apha.2017.03.004. Epub 2017 Jun 5.
10
Endocannabinoids inhibit neurogenic inflammation in murine joints by a non-canonical cannabinoid receptor mechanism.内源性大麻素通过非经典大麻素受体机制抑制鼠关节的神经原性炎症。
Neuropeptides. 2017 Aug;64:131-135. doi: 10.1016/j.npep.2016.08.007. Epub 2016 Aug 22.
Zotero 插件