孕期母体脂谱与新生儿 DNA 甲基化组有关。
Maternal lipodome across pregnancy is associated with the neonatal DNA methylome.
机构信息
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
出版信息
Epigenomics. 2020 Dec;12(23):2077-2092. doi: 10.2217/epi-2020-0234. Epub 2020 Dec 8.
Abstract
To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. The maternal lipidome may be influential in establishing the infant epigenome.
摘要
为了对脐带血白细胞中母体脂质组与 DNA 甲基化的关联进行分类。在密歇根母婴对子队列中，对 100 名母亲的妊娠早期母体血浆（M1）和分娩时母体血浆（M3）进行了非靶向脂质组学分析。使用 Infinium EPIC 珠阵列对脐带血白细胞 DNA 甲基化进行了分析，经验贝叶斯模型确定了与母体脂质组相关的差异 DNA 甲基化。M3 饱和溶血磷脂酰胆碱与 45 个差异甲基化位点相关，M3 饱和溶血磷脂酰乙醇胺与 18 个差异甲基化位点相关。M3 饱和溶血磷脂酰胆碱差异甲基化位点富集的生物学途径与细胞增殖和生长有关。母体脂质组可能对婴儿的表观基因组建立有影响。
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