Hennessy Elizabeth J, FitzGerald Garret A
J Clin Invest. 2021 Feb 1;131(3). doi: 10.1172/JCI144227.
Since the COVID-19 pandemic swept across the globe, researchers have been trying to understand its origin, life cycle, and pathogenesis. There is a striking variability in the phenotypic response to infection with SARS-CoV-2 that may reflect differences in host genetics and/or immune response. It is known that the human epigenome is influenced by ethnicity, age, lifestyle, and environmental factors, including previous viral infections. This Review examines the influence of viruses on the host epigenome. We describe general lessons and methodologies that can be used to understand how the virus evades the host immune response. We consider how variation in the epigenome may contribute to heterogeneity in the response to SARS-CoV-2 and may identify a precision medicine approach to treatment.
自新冠疫情席卷全球以来，研究人员一直在努力了解其起源、生命周期和发病机制。感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后的表型反应存在显著差异，这可能反映了宿主基因和/或免疫反应的不同。众所周知，人类表观基因组受种族、年龄、生活方式和环境因素影响，包括既往病毒感染。本综述探讨病毒对宿主表观基因组的影响。我们描述了可用于理解病毒如何逃避宿主免疫反应的一般经验和方法。我们考虑表观基因组的变异如何导致对SARS-CoV-2反应的异质性，并可能确定一种精准医学治疗方法。
