Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Department of Plastic Surgery, University of Groningen, Groningen, The Netherlands.
Muscle Nerve. 2021 Mar;63(3):421-429. doi: 10.1002/mus.27138. Epub 2020 Dec 20.
Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high-fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal.
RPNIs were constructed by securing skeletal muscle grafts of various masses (150, 300, 600, or 1200 mg) to the divided peroneal nerve. In the control group, the peroneal nerve was transected without repair. Endpoint assessments were conducted 3 mo postoperatively.
Compound muscle action potentials (CMAPs), maximum tetanic isometric force, and specific muscle force were significantly higher for both the 150 and 300 mg RPNI groups compared to the 600 and 1200 mg RPNIs. Larger RPNI muscle groups contained central areas lacking regenerated muscle fibers.
Electrical signaling and tissue viability are optimal in smaller as opposed to larger RPNI constructs in a rat model.
再生周围神经接口（RPNI）可转换神经信号，从而实现神经假体设备的高保真控制。传统上，大鼠 RPNI 是用约 150mg 的游离骨骼肌移植物构建的。目前尚不清楚更大的游离肌肉移植物是否可以使 RPNI 转换更大的信号。
通过将各种质量（150、300、600 或 1200mg）的骨骼肌移植物固定到分离的腓神经上来构建 RPNI。在对照组中，腓神经被切断而不修复。术后 3 个月进行终点评估。
与 600 和 1200mg RPNI 相比，150 和 300mg RPNI 组的复合肌肉动作电位（CMAP）、最大强直等长力和特定肌肉力均显著更高。较大的 RPNI 肌肉群包含缺乏再生肌纤维的中央区域。
在大鼠模型中，与较大的 RPNI 结构相比，较小的 RPNI 结构具有更好的电信号和组织活力。
