迈向系统性红斑狼疮的精准医学
Towards Precision Medicine in Systemic Lupus Erythematosus.
作者信息
Lever Elliott, Alves Marta R, Isenberg David A
机构信息
Centre for Rheumatology, Division of Medicine, University College Hospital London, London, UK.
Internal Medicine, Department of Medicine, Centro Hospitalar do Porto, Porto, Portugal.
出版信息
Pharmgenomics Pers Med. 2020 Feb 4;13:39-49. doi: 10.2147/PGPM.S205079. eCollection 2020.
Abstract
Systemic lupus erythematosus (SLE) is a remarkable condition characterised by diversity amongst its clinical features and immunological abnormalities. In this review, we attempt to capture the major immunological changes linked to the pathophysiology of lupus and discuss the challenge it presents in moving towards the concept of precision medicine. Currently broadly similar types of drugs, e.g., steroids, immunosuppressives, hydroxychloroquine are used to treat many of the diverse clinical features of SLE. We suspect that, as the precise immunopathological abnormalities differ between the various organs/systems in lupus patients, it will be some time before precision medicine can be fully applied to SLE.
摘要
系统性红斑狼疮（SLE）是一种显著的疾病，其临床特征和免疫异常具有多样性。在本综述中，我们试图梳理与狼疮病理生理学相关的主要免疫变化，并讨论在迈向精准医学概念方面所面临的挑战。目前，广泛使用大致类似类型的药物，如类固醇、免疫抑制剂、羟氯喹，来治疗SLE的许多不同临床特征。我们怀疑，由于狼疮患者不同器官/系统的精确免疫病理异常有所不同，精准医学全面应用于SLE还需要一段时间。
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