A.M. Butlerov' Chemistry Institute of Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Analytical Chemistry Department of Chemical Technology Institute of Ural Federal University, 19 Mira Street, 620002 Ekaterinburg, Russia.
Sensors (Basel). 2020 Dec 5;20(23):6963. doi: 10.3390/s20236963.
Metal-organic frameworks (MOFs) offer a unique variety of properties and morphology of the structure that make it possible to extend the performance of existing and design new electrochemical biosensors. High porosity, variable size and morphology, compatibility with common components of electrochemical sensors, and easy combination with bioreceptors make MOFs very attractive for application in the assembly of electrochemical aptasensors. In this review, the progress in the synthesis and application of the MOFs in electrochemical aptasensors are considered with an emphasis on the role of the MOF materials in aptamer immobilization and signal generation. The literature information of the use of MOFs in electrochemical aptasensors is classified in accordance with the nature and role of MOFs and a signal mode. In conclusion, future trends in the application of MOFs in electrochemical aptasensors are briefly discussed.
金属-有机骨架（MOFs）提供了独特的多种性质和结构形态，使其能够扩展现有电化学生物传感器的性能并设计新型电化学生物传感器。高孔隙率、可变性的大小和形态、与电化学传感器常见组件的兼容性以及与生物受体的易于结合，使得 MOFs 在电化学适体传感器的组装中具有很大的吸引力。在本文中，考虑了 MOFs 在电化学适体传感器中的合成和应用方面的进展，重点强调了 MOF 材料在适体固定化和信号产生中的作用。根据 MOFs 的性质和作用以及信号模式对电化学适体传感器中使用 MOFs 的文献信息进行了分类。最后，简要讨论了 MOFs 在电化学适体传感器中的应用的未来趋势。
