Equipe d'Accueil (EA 7460), Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Faculté des Sciences de Santé, Université de Bourgogne, Franche Comté, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
Laboratoire Cellules Souches et Régénération Cellulaire et Tissulaire, Centre Interface Applications Médicales (CIAM), Université Mohammed VI Polytechnique, Ben-Guerir 43 150, Morocco.
Int J Mol Sci. 2020 Dec 4;21(23):9262. doi: 10.3390/ijms21239262.
The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs is a major goal in repair medicine. Stem cells are classified by their potential to differentiate into functional cells. Compared with other sources, adipose-derived stem cells (ADSCs) have the advantage of being abundant and easy to obtain. ADSCs are considered to be tools for replacing, repairing, and regenerating dead or damaged cells. The capacity of ADSCs to maintain their properties depends on the balance of complex signals in their microenvironment. Their properties and the associated outcomes are in part regulated by reactive oxygen species, which mediate the oxidation-reduction state of cells as a secondary messenger. ADSC therapy has demonstrated beneficial effects, suggesting that secreted factors may provide protection. There is evidence that ADSCs secrete a number of cytokines, growth factors, and antioxidant factors into their microenvironment, thus regulating intracellular signaling pathways in neighboring cells. In this review, we introduce the roles of ADSCs in the protection of cells by modulating inflammation and immunity, and we develop their potential therapeutic properties.
基于干细胞的疗法在修复和再生各种组织和器官方面具有广阔的应用前景，这是修复医学的主要目标。干细胞可根据其分化为功能性细胞的潜能进行分类。与其他来源相比，脂肪来源的干细胞 (ADSCs) 具有丰富且易于获取的优势。ADSCs 被认为是替代、修复和再生死亡或受损细胞的工具。ADSCs 维持其特性的能力取决于其微环境中复杂信号的平衡。其特性和相关结果部分受活性氧（ROS）调节，ROS 作为第二信使介导细胞的氧化还原状态。ADSC 疗法已显示出有益的效果，表明分泌因子可能提供保护。有证据表明，ADSCs 将多种细胞因子、生长因子和抗氧化因子分泌到其微环境中，从而调节邻近细胞的细胞内信号通路。在这篇综述中，我们介绍了 ADSCs 通过调节炎症和免疫来保护细胞的作用，并探讨了其潜在的治疗特性。
