Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Institute for Health and Society, Hanyang University, Seoul, Korea.
Int J Food Sci Nutr. 2021 Aug;72(5):615-631. doi: 10.1080/09637486.2020.1856794. Epub 2020 Dec 8.
This meta-analysis was performed to investigate whether calcium supplements and dairy products change obesity indices including fat mass. Original articles published in English between July 2009 and August 2019 were identified. Ten and 14 randomised controlled trials (RCTs) with ≥ 12 weeks interventions of calcium supplements and dairy products among overweight or obese adults aged ≥18 were critically reviewed. Mean difference (MD) or standardised mean difference (SMD) with 95% confidence interval (CI) were obtained using a random effect meta-analysis. Dairy products significantly changed fat mass (SMD, 95% CI; -0.40 [-0.77, -0.02]) and BMI (MD, 95% CI: -0.46 kg/m2 [-0.67, -0.26]), and calcium supplements also showed changes in fat mass (SMD, 95% CI; -0.15[-0.28, -0.02]). However, in the analysis of RCTs with low risk of bias scores, the significant changes remained only in the dairy-products intervention. Our findings suggest that dairy products without distinction of fat percentage may help reduce fat mass and BMI, but calcium supplements may not.
这项荟萃分析旨在探讨钙补充剂和乳制品是否能改变肥胖指数，包括脂肪量。检索了 2009 年 7 月至 2019 年 8 月期间发表的英文原始文章。对纳入的 10 项和 14 项针对超重或肥胖成年人（年龄≥18 岁）的钙补充剂和乳制品干预时间≥12 周的随机对照试验（RCT）进行了严格评价。使用随机效应荟萃分析获得了均值差（MD）或标准化均数差（SMD）及其 95%置信区间（CI）。乳制品显著改变了脂肪量（SMD，95%CI；-0.40[-0.77, -0.02]）和 BMI（MD，95%CI：-0.46kg/m2[-0.67, -0.26]），钙补充剂也改变了脂肪量（SMD，95%CI；-0.15[-0.28, -0.02]）。然而，在低偏倚风险评分的 RCT 分析中，乳制品干预的显著变化仍然存在。我们的研究结果表明，不分脂肪含量的乳制品可能有助于减少脂肪量和 BMI，但钙补充剂可能没有效果。
