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The production of heartwater vaccine.

作者信息

Oberem P T, Bezuidenhout J D

机构信息

Veterinary Research Institute, Onderstepoort.

出版信息

Onderstepoort J Vet Res. 1987 Sep;54(3):485-8.

PMID:3329332
Abstract

The events leading to the production of an effective vaccine against heartwater are summarized. The production techniques used at Onderstepoort to produce and control the quality of the infected blood and nymph suspension vaccines, and covering their respective advantages and disadvantages, are compared. The many problems of these vaccines and how they may be overcome are discussed.

摘要

相似文献

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引用本文的文献

1
The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number.心水病病原体反刍兽埃立克体的基因组包含多个拷贝数可动态变化的串联重复序列。
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):838-43. doi: 10.1073/pnas.0406633102. Epub 2005 Jan 6.
2
Monoclonal antibody binding to a surface-exposed epitope on Cowdria ruminantium that is conserved among eight strains.单克隆抗体与反刍兽考德里氏体表面暴露的一个表位结合,该表位在八个菌株中是保守的。
Clin Diagn Lab Immunol. 2000 Nov;7(6):983-6. doi: 10.1128/CDLI.7.6.983-986.2000.
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Growth of Cowdria ruminantium, the causative agent of heartwater, in a tick cell line.
牛心水病病原体反刍动物考德里氏体在蜱细胞系中的生长
J Clin Microbiol. 2000 Mar;38(3):1238-40. doi: 10.1128/JCM.38.3.1238-1240.2000.
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Identification of Cowdria ruminantium antigens that stimulate proliferation of lymphocytes from cattle immunized by infection and treatment or with inactivated organisms.鉴定通过感染与治疗或用灭活病原体免疫的牛的淋巴细胞增殖所刺激的反刍兽埃立克体抗原。
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Restriction of major surface protein 2 (MSP2) variants during tick transmission of the ehrlichia Anaplasma marginale.边缘无形体蜱传播过程中主要表面蛋白2(MSP2)变体的限制
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Production of alpha interferon in Cowdria ruminantium-infected cattle and its effect on infected endothelial cell cultures.感染反刍兽考德里氏体的牛体内α干扰素的产生及其对受感染内皮细胞培养物的影响。
Infect Immun. 1994 Jun;62(6):2600-4. doi: 10.1128/iai.62.6.2600-2604.1994.
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Development and evaluation of PCR assay for detection of low levels of Cowdria ruminantium infection in Amblyomma ticks not detected by DNA probe.用于检测DNA探针未检测到的钝缘蜱中低水平反刍兽考德里氏体感染的PCR检测方法的开发与评估
J Clin Microbiol. 1995 Jan;33(1):166-72. doi: 10.1128/jcm.33.1.166-172.1995.
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Protective immunity to heartwater (Cowdria ruminantium infection) is acquired after vaccination with in vitro-attenuated rickettsiae.用体外减毒立克次氏体疫苗接种后可获得对心水病(反刍兽考德里氏体感染)的保护性免疫。
Infect Immun. 1991 Feb;59(2):729-31. doi: 10.1128/iai.59.2.729-731.1991.