Antiproliferative Activity, Proapoptotic Effect, and Cell Cycle Arrest in Human Cancer Cells of Some Marine Natural Product Extract.

Bioactive constituents of numerous marine organisms have been investigated recently for their preclinical and clinical anticancer activity. Three marine organisms: black-spotted sea cucumber: (), lollyfish: (), and sea hare: (), were collected during winter 2019 from Gulf of Aqaba, Red Sea, Egypt, and macerated with ethanol into three different extracts: , , and , where each was assessed for its antiproliferative and proapoptotic properties on , , and cancer cells. dose-dependently inhibited the growth of , , and cells within IC values 16.22, 13.34, and 18.09 g/mL, respectively, while the IC values for the antiproliferative activity of were 12.48, 10.45, and 10.36 g/mL, respectively, and the IC values of were 6.51, 5.33, and 6.87 g/mL, respectively. All extracts were found to induce G/G cell cycle arrest for cells side by side with their inhibition of on all three cell lines while all extracts were also showed to induce apoptosis in cell line at pre- phase supplemented by their anticancer activity via proapoptotic protein , , and cleavage increase, and antiapoptotic protein downturn. Moreover, necrosis has been relatively noticed in cell line as an additional anticancer activity for each extract. Our data introduced three ethanolic marine extracts as natural chemotherapeutic agents to be further developed for cancer control.