Henschel Jonas, Hayen Heiko
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149 Münster, Germany.
MethodsX. 2020 Nov 7;7:101134. doi: 10.1016/j.mex.2020.101134. eCollection 2020.
The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples.•The injection volume was raised from 10 µL to 500 µL, while the overall analysis time was only increased by ≈5 min compared to the initial method.•Online column head refocusing and concentration of analytes enabled detection in sub-ng L concentration range without elaborate sample preparation steps.•Relative standard deviations <7% despite multiple injection into the loop.
采用大体积进样与混合模式色谱相结合的方法，对地表水样品中七种理化性质各异的人工甜味剂进行直接超痕量液相色谱-串联质谱分析。•进样体积从10 μL提高到500 μL，而与初始方法相比，总分析时间仅增加了约5分钟。•在线柱端聚焦和分析物浓缩使得无需复杂的样品制备步骤就能在亚纳克/升浓度范围内进行检测。•尽管多次进样到定量环中，相对标准偏差仍<7%。
