Hôpital Fontan, Centre Hospitalier Universitaire de Lille (CHU de Lille), 59037 Lille, France.
University of Lille, Inserm, CHU Lille, U1172-LilNCog-Lille Neurosciences & Cognition, Lille, France.
J Clin Psychiatry. 2020 Dec 8;82(1):20m13641. doi: 10.4088/JCP.20m13641.
To assess the prevalence of and risk factors for posttraumatic stress disorder (PTSD) in patients with COVID-19.
We conducted a cohort study between March and May 2020 at the Lille University Hospital (France), including all patients with laboratory-confirmed COVID-19. Psychological distress symptoms were measured 3 weeks after onset of COVID-19 symptoms using the Impact of Event Scale-6 items (IES-6). The evaluation of PTSD symptoms using the PTSD Checklist for DSM-5 (PCL-5) took place 1 month later. Bivariate analyses were performed to analyze the relationship between PCL-5 scores and the demographic and health variables. The significant variables were then introduced into a multivariable linear regression analysis to establish their relative contributions to the severity of PTSD symptoms.
180 patients were included in this study, and 138 patients completed the 2 evaluations. Among the 180 patients, 70.4% patients required hospitalization, and 30.7% were admitted to the intensive care unit. The prevalence of PTSD was 6.5%, and the predictive factors of PTSD included psychological distress at the onset of the illness and a stay in an intensive care unit.
The prevalence of PTSD in patients with COVID-19 is not as high as that reported among patients during previous epidemics. Initial psychological responses were predictive of a PTSD diagnosis, even though most patients showing acute psychological distress (33.5% of the sample) improved in the following weeks. PTSD symptoms also increased following a stay in an intensive care unit. Future studies should assess the long-term consequences of COVID-19 on patients' mental health.
评估 COVID-19 患者创伤后应激障碍（PTSD）的患病率和危险因素。
我们于 2020 年 3 月至 5 月在里尔大学医院（法国）进行了一项队列研究，纳入所有实验室确诊的 COVID-19 患者。在 COVID-19 症状出现后 3 周，使用事件影响量表-6 项（IES-6）测量心理困扰症状。1 个月后使用 DSM-5 创伤后应激障碍检查表（PCL-5）评估 PTSD 症状。采用单变量分析分析 PCL-5 评分与人口统计学和健康变量之间的关系。然后将有意义的变量引入多变量线性回归分析，以确定它们对 PTSD 症状严重程度的相对贡献。
本研究纳入了 180 例患者，其中 138 例完成了 2 次评估。在 180 例患者中，70.4%的患者需要住院治疗，30.7%的患者入住重症监护病房。PTSD 的患病率为 6.5%，PTSD 的预测因素包括疾病发作时的心理困扰和入住重症监护病房。
COVID-19 患者 PTSD 的患病率不如以往流行期间报告的那么高。最初的心理反应是 PTSD 诊断的预测因素，尽管大多数表现出急性心理困扰的患者（样本的 33.5%）在接下来的几周内有所改善。入住重症监护病房后，PTSD 症状也会增加。未来的研究应评估 COVID-19 对患者心理健康的长期影响。
