Frontiers Science Center for Flexible Electronics (FSCFE), Xian Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), Xi'an 710072, China.
NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
ACS Infect Dis. 2021 Jun 11;7(6):1369-1388. doi: 10.1021/acsinfecdis.0c00646. Epub 2020 Dec 9.
The SARS-CoV-2 outbreak that emerged at the end of 2019 has affected more than 58 million people with more than 1.38 million deaths and has had an incalculable impact on the world . Extensive prevention and treatment measures have been implemented since the pandemic. In this Review, we summarize current understanding on the source, transmission characteristics, and pathogenic mechanism of SARS-CoV-2. We also detail the recent development of diagnostic methods and potential treatment strategies of COVID-19 with focus on the ongoing clinical trials of antibodies, vaccines, and inhibitors for combating the emerging coronavirus.
2019 年底爆发的 SARS-CoV-2 疫情已影响全球超过 5800 万人,造成超过 138 万人死亡,对全球造成了难以估量的影响。自疫情爆发以来,已采取广泛的防治措施。在这篇综述中,我们总结了目前对 SARS-CoV-2 的来源、传播特征和发病机制的认识。我们还详细介绍了 COVID-19 的诊断方法和潜在治疗策略的最新进展,重点介绍了正在进行的针对新型冠状病毒的抗体、疫苗和抑制剂的临床试验。