State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China.
ACS Appl Mater Interfaces. 2020 Dec 23;12(51):56898-56907. doi: 10.1021/acsami.0c19492. Epub 2020 Dec 9.
Inflammation has been assumed to affect the pathology of wound healing and is associated with many nonhealing chronic wounds. Naturally derived herbal medicines with anti-inflammatory properties are of interest because of their effectiveness and affordability in clinical treatment. Herein, we report a supramolecular hydrogel comprising self-assembled natural herb rhein and an oxidative responsive cross-linked network based on ferrocene and β-cyclodextrin host-guest recognitions. Rhein can directly self-assemble into fibrils, exerting better anti-inflammation efficiency than its free drug form. The adaption of the supramolecular network can greatly improve the stability and retain the structural integrity of encapsulated self-assembled rhein. In addition, host-guest recognition confers dissolution of the hydrogel under oxidative stress, thereby delivering self-assembled rhein to the wound site and exerting better therapeutic efficiency. Evaluations in diabetic mice indicate that the resultant hydrogel promoted chronic wound healing by suppressing excess reactive oxygen species, facilitating the transition of the wound healing process, and restoring the normal wound-repair process. Therefore, the proposed hydrogel has a potential value as an herbal-based dressing for future clinical chronic wound management.
炎症被认为会影响伤口愈合的病理过程，并且与许多难以愈合的慢性伤口有关。具有抗炎特性的天然草药药物因其在临床治疗中的有效性和可负担性而受到关注。在此，我们报告了一种包含自组装天然大黄素和基于二茂铁和β-环糊精主客体识别的氧化响应交联网络的超分子水凝胶。大黄素可以直接自组装成纤维，发挥比其游离药物形式更好的抗炎效果。超分子网络的适应性可以极大地提高稳定性并保持封装的自组装大黄素的结构完整性。此外，主体-客体识别赋予水凝胶在氧化应激下的溶解能力，从而将自组装的大黄素递送到伤口部位并发挥更好的治疗效果。在糖尿病小鼠中的评估表明，所得水凝胶通过抑制过量的活性氧来促进慢性伤口愈合，促进伤口愈合过程的转变，并恢复正常的伤口修复过程。因此，该水凝胶作为一种基于草药的敷料具有潜在的价值，可用于未来的临床慢性伤口管理。
