Krishnamurthy Praveen Thaggikuppe
Department of Pharmacology, JSS College of Pharmacy, (A constituent College of JSS Academy of Higher Education & Research), Ooty, Tamilnadu,India.
Infect Disord Drug Targets. 2021;21(8):e160921188929. doi: 10.2174/1871526520666201209145302.
The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARSCoV- 2 virology, its target structural proteins (S-glycoprotein), non-structural proteins (3-chymotrypsin- like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high- -throughput screening), and the current status of antiviral drug development.
2019年冠状病毒病是由新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的大流行病，正严重影响全球健康和经济。由于疫苗研发需要时间，目前的研究集中在重新利用美国食品药品监督管理局（FDA）批准的药物来对抗病毒靶蛋白。本综述讨论了目前对SARS-CoV-2病毒学的理解，其靶结构蛋白（S糖蛋白）、非结构蛋白（3-糜蛋白酶样蛋白酶、木瓜蛋白酶样蛋白酶、RNA依赖性RNA聚合酶和解旋酶）及辅助蛋白，药物发现策略（药物重新利用、人工智能和高通量筛选），以及抗病毒药物开发的现状。
