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鉴定肝癌患者中与 RNA 结合蛋白相关的基因特征。

Identification of an RNA binding protein-related gene signature in hepatocellular carcinoma patients.

机构信息

Precision Medicine Center of Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

出版信息

Mol Med. 2020 Dec 9;26(1):125. doi: 10.1186/s10020-020-00252-5.

DOI:10.1186/s10020-020-00252-5
PMID:33297932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7727152/
Abstract

BACKGROUND

Hepatocellular carcinoma (HCC) is a common malignant primary cancer with high mortality. Previous studies have demonstrated that RNA binding proteins (RBPs) are involved in the biological processes of cancers, including hepatocellular cancer.

METHODS

In this study, we aimed to identify the clinical value of RNA-binding proteins for hepatocellular carcinoma. We obtained gene expression and clinical data of hepatocellular carcinoma patients from the TCGA and ICGC databases. The prognostic value of RBP-related genes in patients with hepatocellular carcinoma and their function were studied by comprehensive bioinformatics analyses. The gene signature of SMG5, EZH2, FBLL1, ZNF239, and IGF2BP3 was generated by univariate and multivariate Cox regression and LASSO regression analyses. We built and verified a prognostic nomogram based on RBP-related genes. The gene signature was validated by the ICGC database. The expression of RBP-related genes was validated by the Oncomine database, the Human Protein Atlas and Kaplan-Meier plotter.

RESULT

Most RBP-related genes were significantly different in cancer and normal tissues. The survival of patients in the different groups was significantly different. The gene signature showed good performance for predicting the survival of HCC patients by having a better area under the receiver operating characteristic curve than other clinicopathological parameters.

CONCLUSION

Gene signatures based on RNA-binding proteins can be independent risk factors for hepatocellular carcinoma patients.

摘要

背景

肝细胞癌（HCC）是一种常见的恶性原发性癌症，死亡率很高。先前的研究表明，RNA 结合蛋白（RBPs）参与癌症的生物学过程，包括肝细胞癌。

方法

在这项研究中，我们旨在确定 RNA 结合蛋白在肝细胞癌中的临床价值。我们从 TCGA 和 ICGC 数据库中获得了肝细胞癌患者的基因表达和临床数据。通过综合生物信息学分析研究了 RBP 相关基因在肝细胞癌患者中的预后价值及其功能。通过单变量和多变量 Cox 回归以及 LASSO 回归分析生成了 SMG5、EZH2、FBLL1、ZNF239 和 IGF2BP3 的基因特征。我们基于 RBP 相关基因构建并验证了预后列线图。该基因特征通过 ICGC 数据库进行了验证。通过 Oncomine 数据库、人类蛋白质图谱和 Kaplan-Meier plotter 验证了 RBP 相关基因的表达。

结果

大多数 RBP 相关基因在癌症和正常组织中差异显著。不同组患者的生存情况存在显著差异。该基因特征通过具有比其他临床病理参数更好的受试者工作特征曲线下面积，表现出对 HCC 患者生存预测的良好性能。

结论

基于 RNA 结合蛋白的基因特征可以成为肝细胞癌患者的独立危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/58980a30c638/10020_2020_252_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/57930e4b7631/10020_2020_252_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/a07e59ff8f55/10020_2020_252_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/a05d2df8c1f4/10020_2020_252_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/b3c328f9d58d/10020_2020_252_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/2dfcba93fa6f/10020_2020_252_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/da26311d2e24/10020_2020_252_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/09ad360a16f3/10020_2020_252_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/66fad57989a5/10020_2020_252_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/58980a30c638/10020_2020_252_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/57930e4b7631/10020_2020_252_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/a07e59ff8f55/10020_2020_252_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/a05d2df8c1f4/10020_2020_252_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/b3c328f9d58d/10020_2020_252_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/2dfcba93fa6f/10020_2020_252_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/da26311d2e24/10020_2020_252_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/09ad360a16f3/10020_2020_252_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/66fad57989a5/10020_2020_252_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e15e/7727152/58980a30c638/10020_2020_252_Fig9_HTML.jpg

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