Srinivasan Shriya S, Tuckute Greta, Zou Jasmine, Gutierrez-Arango Samantha, Song Hyungeun, Barry Robert L, Herr Hugh M
Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
MIT Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sci Transl Med. 2020 Dec 9;12(573). doi: 10.1126/scitranslmed.abc5926.
The brain undergoes marked changes in function and functional connectivity after limb amputation. The agonist-antagonist myoneural interface (AMI) amputation is a procedure that restores physiological agonist-antagonist muscle relationships responsible for proprioceptive sensory feedback to enable greater motor control. We compared results from the functional neuroimaging of individuals ( = 29) with AMI amputation, traditional amputation, and no amputation. Individuals with traditional amputation demonstrated a significant decrease in proprioceptive activity, measured by activation of Brodmann area 3a, whereas functional activation in individuals with AMIs was not significantly different from controls with no amputation ( < 0.05). The degree of proprioceptive activity in the brain strongly correlated with fascicle activity in the peripheral muscles and performance on motor tasks ( < 0.05), supporting the mechanistic basis of the AMI procedure. These results suggest that surgical techniques designed to restore proprioceptive peripheral neuromuscular constructs result in desirable central sensorimotor plasticity.
肢体截肢后，大脑的功能和功能连接会发生显著变化。主动肌 - 拮抗肌肌神经接口（AMI）截肢术是一种恢复负责本体感觉反馈的生理主动肌 - 拮抗肌关系的手术，以实现更好的运动控制。我们比较了29名接受AMI截肢术、传统截肢术和未截肢个体的功能神经成像结果。通过布罗德曼3a区的激活来测量，接受传统截肢术的个体本体感觉活动显著下降，而接受AMI截肢术的个体的功能激活与未截肢的对照组没有显著差异（P<0.05）。大脑中的本体感觉活动程度与外周肌肉中的束状活动以及运动任务表现密切相关（P<0.05），这支持了AMI手术的机制基础。这些结果表明，旨在恢复本体感觉外周神经肌肉结构的手术技术会导致理想的中枢感觉运动可塑性。
