Liu Yin, Yu Yanbing, Wang Zheng, Deng Zhu, Liu Ruiquan, Luo Na, Zhang Li
Graduate School of Peking University Health Science Center, Beijing, People's Republic of China.
Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, People's Republic of China.
J Pain Res. 2020 Dec 1;13:3207-3215. doi: 10.2147/JPR.S279674. eCollection 2020.
Microvascular decompression (MVD) is the most effective surgical procedure for the treatment of refractory primary trigeminal neuralgia (TN), but due to the presence of non-neurovascular compression (NVC), the application of MVD is limited. In some cases, partial sensory rhizotomy (PSR) is required. The purpose of this study was to compare the outcome of MVD and MVD+PSR in the treatment of primary TN and to evaluate the application value of PSR in the treatment of TN.
We retrospectively analyzed the postoperative outcomes of patients who received MVD or MVD+PSR for the first time from the same surgeon in the neurosurgery department of China-Japan Friendship Hospital from March 2009 to December 2017. A total of 105 patients were included in the data analysis, including 40 in the MVD group and 65 in the MVD+PSR group.
The MVD group had an effectiveness rate of 60% and a recurrence rate of 31.4% after an average follow-up of 49.4 months. The MVD+PSR group had an average effectiveness rate of 69.2% and a recurrence rate of 28.6% after an average follow-up of 71.4 months. There was no statistically significant intergroup difference in long-term effectiveness (p=0.333) or recurrence rates (p=0.819). The incidence of facial numbness was significantly higher in the MVD+PSR group than in the MVD group (83.1% vs 7.5%; p<0.001). However, facial numbness had no significant effect on the patients' daily life.
MVD+PSR and MVD have the same effectiveness in the treatment of primary TN. MVD+PSR is associated with a higher incidence of facial numbness than MVD, but the difference does not affect the patients' daily life. PSR should have a place in the treatment of TN by posterior fossa microsurgery.
微血管减压术(MVD)是治疗难治性原发性三叉神经痛(TN)最有效的外科手术,但由于存在非神经血管压迫(NVC),MVD的应用受到限制。在某些情况下,需要进行部分感觉神经根切断术(PSR)。本研究的目的是比较MVD和MVD+PSR治疗原发性TN的疗效,并评估PSR在TN治疗中的应用价值。
我们回顾性分析了2009年3月至2017年12月在中国-日本友好医院神经外科由同一位外科医生首次接受MVD或MVD+PSR治疗的患者的术后结果。共有105例患者纳入数据分析,其中MVD组40例,MVD+PSR组65例。
MVD组平均随访49.4个月后有效率为60%,复发率为31.4%。MVD+PSR组平均随访71.4个月后有效率平均为69.2%,复发率为28.6%。长期疗效(p=0.333)或复发率(p=0.819)组间差异无统计学意义。MVD+PSR组面部麻木发生率明显高于MVD组(83.1%对7.5%;p<0.001)。然而,面部麻木对患者日常生活无明显影响。
MVD+PSR和MVD治疗原发性TN疗效相同。MVD+PSR比MVD面部麻木发生率更高,但差异不影响患者日常生活。PSR在颅后窝显微手术治疗TN中应有一席之地。