Borodulina E A, Vasneva Zh P, Borodulin B E, Vdoushkina E S, Povalyaeva L V, Mateesku K A
«Samara state medical University» of the Ministry of Health of Russia.
«Samara diagnostic center».
Klin Lab Diagn. 2020 Dec 4;65(11):676-682. doi: 10.18821/0869-2084-2020-65-11-676-682.
During the pandemic of a new coronavirus infection one of the most serious complications is pneumonia. When entering a specialized pulmonology Department, the presence of pneumonia is confirmed by computed tomography (CT), the etiology is confirmed by the detection of SARS-CoV-2 RNA by PCR, the article analyzes the indicators of blood analysis when patients are admitted to the hospital. All admitted patients were divided into 2 groups. Group 1 of the study - with a new coronavirus infection Covid-19, confirmed by the detection of PCR-RNA SARS-CoV-2 (n=27). Group 2 consisted of 65 patients (70.7%) with lung tissue damage characteristic of Covid-19 according to CT, who had a negative analysis of PCR-RNA SARS-CoV-2. Statistically significant deviations were shown in a decrease in the percentage and absolute content of lymphocytes, monocytes and platelets, and an increase in neutrophils. The comparative analysis in the groups with positive and negative PCR analysis for the detection of SARS-CoV-2 RNA showed no statistically significant differences. It can be assumed that with the similarity of clinical manifestations and CT-data, a negative result of PCR-RNA SARS-CoV-2 can be diagnosed as «lung damage caused by COVID-19 infection».
在新型冠状病毒感染大流行期间，最严重的并发症之一是肺炎。进入专业肺病科时，通过计算机断层扫描（CT）确认肺炎的存在，通过聚合酶链反应（PCR）检测严重急性呼吸综合征冠状病毒2（SARS-CoV-2）RNA来确认病因，本文分析了患者入院时血液分析的指标。所有入院患者分为2组。研究的第1组——通过检测PCR-RNA SARS-CoV-2确诊为新型冠状病毒感染新冠病毒病（Covid-19）（n = 27）。第2组由65名患者（70.7%）组成，根据CT检查，这些患者具有Covid-19特征性的肺组织损伤，其PCR-RNA SARS-CoV-2分析结果为阴性。淋巴细胞、单核细胞和血小板的百分比及绝对含量降低，中性粒细胞增加，呈现出统计学上的显著差异。对检测SARS-CoV-2 RNA的PCR分析呈阳性和阴性的两组进行比较分析，未发现统计学上的显著差异。可以假设，在临床表现和CT数据相似的情况下，PCR-RNA SARS-CoV-2检测结果为阴性可诊断为“COVID-19感染引起的肺损伤”。
