Dept. of Orthopaedic Surgery, Clinical Orthopaedic Research Hvidovre (CORH), Copenhagen University Hospital Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Copenhagen, Denmark.
Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD, UK.
J Clin Epidemiol. 2021 Apr;132:18-25. doi: 10.1016/j.jclinepi.2020.12.007. Epub 2020 Dec 8.
The objective of the study was to create an interpretive categorical classification for the transition in the Oxford Knee Score (OKS) change score (ΔOKS) using the anchor-based method.
Registry data from 46,094 total knee replacements from the year 2014/15, were accessed via the Health and Social Care Information Center official website. Data included preoperative and 6-month follow-up OKS and response to the transition anchor question. Categories were determined using Gaussian approximation probability and k-fold cross-validation.
Four categories were identified with the corresponding ΔOKS intervals: "1. much better" (≥16), "2. a little better" (7-15), "3. about the same" (1-6), and "4. much worse" (≤0) based on the anchor questions' original five categories. The mean 10-fold cross-validation error was 0.35 OKS points (95% confidence interval 0.12 to 0.63). Sensitivity ranged from 0.34 to 0.68; specificity ranged from 0.74 to 0.95.
We have categorized the change score into a clinically meaningful classification. We argue it should be an addition to the continuous OKS outcome to contextualize the results in a way more applicable to the shared decision-making process and for interpreting research results.
本研究旨在采用基于锚点的方法,为牛津膝关节评分(OKS)变化评分(ΔOKS)的转变创建解释性分类。
通过卫生和社会保健信息中心官方网站访问了 2014/15 年总计 46094 例全膝关节置换术的登记数据。数据包括术前和 6 个月随访时的 OKS 以及对转变锚定问题的反应。类别是使用高斯逼近概率和 k 折交叉验证确定的。
根据锚定问题的原始五个类别,确定了四个类别,相应的ΔOKS 区间为:“1. 明显改善”(≥16)、“2. 略有改善”(7-15)、“3. 大致相同”(1-6)和“4. 明显恶化”(≤0)。10 倍交叉验证的平均误差为 0.35 OKS 点(95%置信区间为 0.12 至 0.63)。敏感性范围为 0.34 至 0.68;特异性范围为 0.74 至 0.95。
我们已经将变化评分分为一个具有临床意义的分类。我们认为,这应该是对连续 OKS 结果的补充,以便以更适用于共同决策过程和解释研究结果的方式对结果进行上下文化。