Chen Xu, Guo Qianping, Chen Wei, Xie Wanli, Wang Yunlong, Wang Miao, You Tianyan, Pan Guoqing
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, P. R. China.
Orthopaedic Institute, Department of Orthopaedic Surgery, The First Affiliated Hospital, Medical College, Soochow University, Suzhou, Jiangsu 215006, P. R. China.
Acta Biomater. 2021 Feb;121:143-179. doi: 10.1016/j.actbio.2020.12.008. Epub 2020 Dec 7.
Photonic crystal (PC) materials with bio-inspired structure colors have drawn increasing attention as their potentials have been rapidly progressed in the field of biomedicine. After elaborate integration with smart materials or preparations through advanced techniques, PC materials have shown significant advantages in biosensing, bio-probing, bio-screening, tissue engineering, and so forth. In this review, we first introduced the fundamentals of PC materials as well as their fabrication strategies with different dimensional outputs. Based on these diversified PC materials, their biomedical potentials as biosensing elements, cell carriers, drug delivery systems, screening methods, cell scaffolds for tissue engineering, cell imaging probes, as well as the monitoring means for biological processes were then highlighted. In addition to these, we finally listed and discussed some emerging applications of PCs integrated with functional materials and newly developed material engineering technologies. In short, this review will provide a panoramic view of PCs-based biomedicines, and moreover, the progressive discussions from fundamentals to advanced applications in this review may also encourage researchers to innovate PC materials or devices for broader biomedical applications.
具有仿生结构颜色的光子晶体（PC）材料因其在生物医学领域的潜力迅速发展而受到越来越多的关注。通过先进技术与智能材料精心整合或制备后，PC材料在生物传感、生物探测、生物筛选、组织工程等方面显示出显著优势。在本综述中，我们首先介绍了PC材料的基本原理及其具有不同维度输出的制备策略。基于这些多样化的PC材料，随后重点介绍了它们作为生物传感元件、细胞载体、药物递送系统、筛选方法、组织工程细胞支架、细胞成像探针以及生物过程监测手段的生物医学潜力。除此之外，我们最后列出并讨论了一些与功能材料集成的PC以及新开发的材料工程技术的新兴应用。简而言之，本综述将提供基于PC的生物医学的全景视图，此外，本综述中从基础到先进应用的渐进讨论也可能鼓励研究人员创新PC材料或设备以用于更广泛的生物医学应用。
