State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
J Evid Based Dent Pract. 2020 Dec;20(4):101485. doi: 10.1016/j.jebdp.2020.101485. Epub 2020 Aug 24.
To estimate the association of human papillomavirus (HPV) infection with oral lichen planus (OLP) and oral leukoplakia (OLK), and determine risk cofactors.
Seven databases were searched for case-control or cross-sectional studies of OLP and OLK with healthy controls, published between 1976 and 2020. The Meta package of R software was applied to calculate the pooled odds ratios (OR) and 95% confidence interval (CI).
Thirty-six articles were finally included. OLP and OLK cases had a higher association with HPV infection than controls (OLP: OR: 4.91, 95% CI: 2.76-8.72; OLK: OR: 2.51, 95% CI: 1.55-4.07). In subgroup analyses, the OR of HPV infection was higher with erosive lesions than with nonerosive lesions (OLP: OR: 5.36 and 3.47, respectively; OLK: OR: 3.34 and 3.21, respectively). Oral lesions were more strongly associated with HPV16/18 than with HPV6/11 (OLP: OR: 7.84 and 1.42, respectively; OLK: OR: 6.05 and 1.87, respectively) and varied by geographic region (OLP: OR: 4.01-7.02; OLK: OR: 1.46-27.13).
Oral HPV infection, particularly infection with HPV 16/18, was strongly associated with OLP and OLK. Risk cofactors included erosive lesions and geographic region.
评估人乳头瘤病毒（HPV）感染与口腔扁平苔藓（OLP）和口腔白斑（OLK）的相关性，并确定风险因素。
检索了 1976 年至 2020 年间发表的关于 OLP 和 OLK 与健康对照的病例对照或横断面研究的 7 个数据库。R 软件的 Meta 包用于计算合并的优势比（OR）和 95%置信区间（CI）。
最终纳入 36 篇文章。与对照组相比，OLP 和 OLK 病例与 HPV 感染的相关性更高（OLP：OR：4.91，95%CI：2.76-8.72；OLK：OR：2.51，95%CI：1.55-4.07）。亚组分析显示，糜烂性病变的 HPV 感染 OR 高于非糜烂性病变（OLP：OR：5.36 和 3.47；OLK：OR：3.34 和 3.21）。口腔病变与 HPV16/18 的相关性强于 HPV6/11（OLP：OR：7.84 和 1.42；OLK：OR：6.05 和 1.87），且与地理位置有关（OLP：OR：4.01-7.02；OLK：OR：1.46-27.13）。
口腔 HPV 感染，尤其是 HPV16/18 感染，与 OLP 和 OLK 密切相关。风险因素包括糜烂性病变和地理位置。
