Nishioka Hiroaki, Kanzawa Yohei
Department of General Internal Medicine Kobe City Medical Center General Hospital Kobe Japan.
Department of General Internal Medicine Akashi Medical Center Akashi Japan.
J Gen Fam Med. 2020 Jun 15;21(6):256-257. doi: 10.1002/jgf2.338. eCollection 2020 Nov.
Antihistamines are known risk factors for restless legs syndrome (RLS). However, reports on RLS associated with fexofenadine or its combinations are rare. Here, we report a 30-year-old woman with RLS that was induced by fexofenadine/pseudoephedrine. She had been taking fexofenadine/pseudoephedrine for three months and felt a strong urge to move her legs at night, which was relieved by movement. Her condition improved by taking pramipexole, which she discontinued subsequently because of dizziness. One month later, she quitted taking fexofenadine/pseudoephedrine, after which her symptoms disappeared a week later. This case study demonstrates that RLS can be induced by fexofenadine/pseudoephedrine and we should always consider the possibility of drug-induced RLS.
抗组胺药是已知的不安腿综合征（RLS）的风险因素。然而，关于非索非那定或其组合引起RLS的报道很少。在此，我们报告一名30岁女性因非索非那定/伪麻黄碱诱发RLS。她服用非索非那定/伪麻黄碱三个月，夜间感到强烈的腿部活动冲动，活动后缓解。服用普拉克索后她的病情有所改善，但随后因头晕停药。一个月后，她停止服用非索非那定/伪麻黄碱，一周后症状消失。本病例研究表明，非索非那定/伪麻黄碱可诱发RLS，我们应始终考虑药物性RLS的可能性。
