Wongjarupong Nicha, Yonli Albert Theophane, Nagalo Bolni Marius, Djigma Florencia Wendkuuni, Somda Sosthene Kounpielime, Hassan Mohamed A, Mohamed Essa A, Sorgho Abel Pegdwende, Compaore Tegwinde Rebeca, Soubeiga Serge Theophile, Kiendrebeogo Isabelle, Sanou Mahamoudou, Diarra Birama, Yang Hwai-I, Chen Chien-Jen, Ouattara Abdoul K, Zohoncon Théodora M, Martinson Jeremy J, Buetow Kenneth, Chamcheu Jean Christopher, Antwi Samuel O, Borad Mitesh J, Simpore Jacques, Roberts Lewis R
Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN.
Department of Biochemistry and Microbiology Pietro Annigonni Biomolecular Research Center Ouagadougou Burkina Faso West Africa.
Hepatol Commun. 2020 Sep 15;4(12):1781-1792. doi: 10.1002/hep4.1595. eCollection 2020 Dec.
Hepatitis B virus (HBV) genotype E (HBV-E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV-E-induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC-) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC- and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC- group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC- with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06-1.10 per 1-year increase in age), male sex (OR, 2.03; 95% CI, 1.11-3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31-1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. HBV-E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa.
乙型肝炎病毒（HBV）E基因型（HBV-E）在西非慢性乙型肝炎（CHB）感染中占大多数。我们旨在确定与西非HBV-E诱导的肝细胞癌（HCC）相关的因素。分析了来自布基纳法索的乙型肝炎表面抗原阳性（HBsAg+）且患有CHB的患者的数据。在3885例无HCC的CHB患者（CHB HCC-）和59例有HCC的CHB患者（CHB HCC+）中测量了HBV病毒载量和乙型肝炎e抗原（HBeAg）状态。对364例CHB HCC-患者和41例CHB HCC+患者进行了HBV基因分型。总体而言，CHB HCC-组中2.5%为HBeAg+，而CHB HCC+组中为0%。在364例可进行基因分型的CHB HCC-患者中，HBV E基因型和C/E基因型的频率分别为70.3%和12.9%。年龄（年龄每增加1岁，老年的优势比[OR]为1.08；95%置信区间[CI]，1.06 - 1.10）、男性（OR，2.03；95% CI，1.11 - 3.69）和HBV病毒血症（每增加1 log10 IU/mL，OR为1.48；95% CI，1.31 - 1.67）均与HCC诊断相关。与C/E基因型患者相比，E基因型患者的HBeAg流行率较低（6.3%对14.9%），HBV病毒载量较低，肝硬化患病率较高（14.5%对4.8%）。HBV-E是西非患者中最常见的流行毒株（70.3%）。HCC与老年、男性和高HBV病毒载量相关。预计这些结果将进一步为西非HBV感染的临床管理指导提供信息。
