Main A, Dowson A, Gross M
European Institute of Health and Medical Sciences, St. Lukes Hospital, Guildford, England.
Headache. 1997 Sep;37(8):492-5. doi: 10.1046/j.1526-4610.1997.3708492.x.
This study investigated whether migraineurs are more sensitive to light and sound while headache-free than are healthy people. Fifty-two migraineurs (mean age 39 years) were selected using the International Headache Society diagnostic criteria for migraine. Forty-eight healthy controls were matched for age, sex, and race (mean age 36 years). Visual and auditory discomfort thresholds were measured by exposing subjects to increasing light and sound until they complained of discomfort. There were significant differences between groups in both the light discomfort threshold (P < 0.00005) and the hearing discomfort threshold (P < 0.0005). The thresholds for both were lower in the migraineurs. Overall, for both groups together, there was a significant negative correlation between light discomfort threshold and age (correlation coefficient -0.2276, P = 0.011), but not for the hearing discomfort threshold and age (P = 0.275). The results show that the migraineurs were significantly more sensitive to light and sound when headache-free than were healthy controls. The apparent increased intolerance to light in both groups together noted with increased age, did not apply to the migraine group.
本研究调查了偏头痛患者在无头痛发作时是否比健康人对光和声音更敏感。采用国际头痛协会的偏头痛诊断标准选取了52名偏头痛患者（平均年龄39岁）。选取了48名年龄、性别和种族相匹配的健康对照者（平均年龄36岁）。通过让受试者暴露于逐渐增强的光和声音中直至他们主诉不适来测量视觉和听觉不适阈值。两组在光不适阈值（P < 0.00005）和听觉不适阈值（P < 0.0005）方面均存在显著差异。偏头痛患者的这两个阈值均较低。总体而言，对于两组而言，光不适阈值与年龄之间存在显著负相关（相关系数 -0.2276，P = 0.011），但听觉不适阈值与年龄之间不存在显著负相关（P = 0.275）。结果表明，偏头痛患者在无头痛发作时对光和声音的敏感程度显著高于健康对照者。两组总体上随年龄增长对光的不耐受性明显增加，但这一情况不适用于偏头痛组。
