Li Zhen, Huang Jun, Wu Jun
School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, PR. China.
Biomater Sci. 2021 Feb 9;9(3):574-589. doi: 10.1039/d0bm01729a.
As a commonly used treatment method for cancer, chemotherapy is greatly limited by the side effects of chemotherapy drugs and the multiple drug resistance that develops. Nanogels are considered ideal drug carriers due to their high stability, high water content and excellent drug loading capacities. To achieve more precise and intelligent drug delivery in tumor tissues, various environmentally responsive nanogels have been widely developed. Compared to normal tissue, tumor tissue exhibits a lower pH value. Therefore, the pH gradients between the tumor microenvironment and the normal physiological environment can be used to design pH-sensitive nanogels to regulate the delivery and release of antitumor drugs. This article mainly introduces the application of pH-sensitive nanogels in cancer treatment, hoping to provide a reference for the development of cancer treatment.
作为一种常用的癌症治疗方法，化疗受到化疗药物副作用和产生的多药耐药性的极大限制。纳米凝胶因其高稳定性、高含水量和出色的载药能力而被认为是理想的药物载体。为了在肿瘤组织中实现更精确、智能的药物递送，各种环境响应型纳米凝胶已得到广泛开发。与正常组织相比，肿瘤组织的pH值较低。因此，肿瘤微环境与正常生理环境之间的pH梯度可用于设计pH敏感型纳米凝胶，以调节抗肿瘤药物的递送和释放。本文主要介绍pH敏感型纳米凝胶在癌症治疗中的应用，希望为癌症治疗的发展提供参考。
