• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought.对大脑漫游状态的神经调节:神经调质、尖波-涟漪和自发性思维之间的相互作用。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb;376(1817):20190699. doi: 10.1098/rstb.2019.0699. Epub 2020 Dec 14.
2
Mind-Wandering in People with Hippocampal Damage.海马体损伤患者的思维漫游。
J Neurosci. 2018 Mar 14;38(11):2745-2754. doi: 10.1523/JNEUROSCI.1812-17.2018. Epub 2018 Feb 12.
3
Hallucinations as intensified forms of mind-wandering.幻觉是思维漫游的强化形式。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb;376(1817):20190700. doi: 10.1098/rstb.2019.0700. Epub 2020 Dec 14.
4
Offline perception: an introduction.离线感知:引言。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb;376(1817):20190686. doi: 10.1098/rstb.2019.0686. Epub 2020 Dec 14.
5
The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation.海马体中的尖波涟漪在即时使用和巩固记忆检索中的作用。
Nat Rev Neurosci. 2018 Dec;19(12):744-757. doi: 10.1038/s41583-018-0077-1.
6
How deep is the rift between conscious states in sleep and wakefulness? Spontaneous experience over the sleep-wake cycle.睡眠和清醒状态之间的意识状态差距有多大?睡眠-觉醒周期中的自发性体验。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb;376(1817):20190696. doi: 10.1098/rstb.2019.0696. Epub 2020 Dec 14.
7
Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration.海马体萎缩和内在脑网络功能障碍与神经退行性变中思维漫游的改变有关。
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3316-3321. doi: 10.1073/pnas.1818523116. Epub 2019 Feb 4.
8
Shaped by our thoughts--a new task to assess spontaneous cognition and its associated neural correlates in the default network.受我们的思想塑造——一项评估默认网络中自发认知及其相关神经关联的新任务。
Brain Cogn. 2015 Feb;93:1-10. doi: 10.1016/j.bandc.2014.11.001. Epub 2014 Nov 18.
9
Hippocampal sharp-wave ripples linked to visual episodic recollection in humans.海马体锐波涟漪与人类的视觉情景记忆有关。
Science. 2019 Aug 16;365(6454). doi: 10.1126/science.aax1030.
10
Coordinated Interaction between Hippocampal Sharp-Wave Ripples and Anterior Cingulate Unit Activity.海马体尖波涟漪与前扣带回神经元活动之间的协同相互作用。
J Neurosci. 2016 Oct 12;36(41):10663-10672. doi: 10.1523/JNEUROSCI.1042-16.2016.

引用本文的文献

1
Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain.绘制人类大脑中主要神经递质系统的跨模态功能连接图谱。
Brain Struct Funct. 2025 Aug 19;230(7):137. doi: 10.1007/s00429-025-02996-4.
2
Serotonin Modulation of Dorsoventral Hippocampus in Physiology and Schizophrenia.5-羟色胺对生理和精神分裂症中背腹侧海马体的调节作用
Int J Mol Sci. 2025 Jul 27;26(15):7253. doi: 10.3390/ijms26157253.
3
Dopamine alters functional gradients in Parkinson's disease.多巴胺改变帕金森病中的功能梯度。
Imaging Neurosci (Camb). 2025 May 6;3. doi: 10.1162/imag_a_00564. eCollection 2025.
4
Oscillations of the Wandering Mind: Neural Evidence for Distinct Exploration/Exploitation Strategies in Younger and Older Adults.走神的振荡:年轻人和老年人不同探索/利用策略的神经证据
Hum Brain Mapp. 2025 Apr 15;46(6):e70174. doi: 10.1002/hbm.70174.
5
On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS).论意识体验的多样性:迷幻药作用下的信念改变(ALBUS)
Neurosci Conscious. 2025 Feb 13;2025(1):niae038. doi: 10.1093/nc/niae038. eCollection 2025.
6
Individual variability in neural representations of mind-wandering.走神的神经表征中的个体差异。
Netw Neurosci. 2024 Oct 1;8(3):808-836. doi: 10.1162/netn_a_00387. eCollection 2024.
7
Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.帕金森病中的视幻觉:聚焦中枢胆碱能功能障碍
Brain. 2025 Feb 3;148(2):376-393. doi: 10.1093/brain/awae289.
8
Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.强迫症患者额顶叶网络的趋同功能变化:基于体素的荟萃分析
Front Psychiatry. 2024 Jul 8;15:1401623. doi: 10.3389/fpsyt.2024.1401623. eCollection 2024.
9
Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming.建模θ-γ 耦合对序列记忆、想象和做梦的贡献。
Front Neural Circuits. 2024 Jun 14;18:1326609. doi: 10.3389/fncir.2024.1326609. eCollection 2024.
10
Hippocampal sharp-wave ripples correlate with periods of naturally occurring self-generated thoughts in humans.海马体锐波涟漪与人类自然产生自主思维的时期相关。
Nat Commun. 2024 May 22;15(1):4078. doi: 10.1038/s41467-024-48367-1.

本文引用的文献

1
Cortical State Fluctuations during Sensory Decision Making.感觉决策过程中的皮质状态波动。
Curr Biol. 2020 Dec 21;30(24):4944-4955.e7. doi: 10.1016/j.cub.2020.09.067. Epub 2020 Oct 22.
2
Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples.海马体尖波涟漪周围新皮层活动的时空模式。
Elife. 2020 Mar 13;9:e51972. doi: 10.7554/eLife.51972.
3
Mind-wandering in Parkinson's disease hallucinations reflects primary visual and default network coupling.帕金森病幻觉中的思维游荡反映了初级视觉网络与默认网络的耦合。
Cortex. 2020 Apr;125:233-245. doi: 10.1016/j.cortex.2019.12.023. Epub 2020 Jan 22.
4
A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning.蓝斑在空间奖励学习中海马 CA1 位置细胞重组织中的作用。
Neuron. 2020 Mar 18;105(6):1018-1026.e4. doi: 10.1016/j.neuron.2019.12.029. Epub 2020 Jan 21.
5
Multimodal mapping and analysis of the cyto- and receptorarchitecture of the human hippocampus.人类海马体的细胞和受体结构的多模态映射和分析。
Brain Struct Funct. 2020 Apr;225(3):881-907. doi: 10.1007/s00429-019-02022-4. Epub 2020 Jan 18.
6
Dynamic internal states shape memory retrieval.动态内部状态塑造记忆检索。
Neuropsychologia. 2020 Feb 17;138:107328. doi: 10.1016/j.neuropsychologia.2019.107328. Epub 2019 Dec 27.
7
Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks.背侧和腹侧海马体锐波激活不同的伏隔核网络。
Neuron. 2020 Feb 19;105(4):725-741.e8. doi: 10.1016/j.neuron.2019.11.022. Epub 2019 Dec 18.
8
Why does the mind wander?为什么思绪会游离?
Neurosci Conscious. 2019 Oct 22;2019(1):niz014. doi: 10.1093/nc/niz014. eCollection 2019.
9
Spontaneous Thought as an Unconstrained Memory Process.自发性思维作为一种不受约束的记忆过程。
Trends Neurosci. 2019 Nov;42(11):763-777. doi: 10.1016/j.tins.2019.09.001. Epub 2019 Oct 15.
10
Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts.衰老与漫游的大脑:刺激无关思维的神经相关性的年龄相关差异。
PLoS One. 2019 Oct 15;14(10):e0223981. doi: 10.1371/journal.pone.0223981. eCollection 2019.

对大脑漫游状态的神经调节:神经调质、尖波-涟漪和自发性思维之间的相互作用。

Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought.

机构信息

Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine, University of Sydney, Sydney, Australia.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2021 Feb;376(1817):20190699. doi: 10.1098/rstb.2019.0699. Epub 2020 Dec 14.

DOI:10.1098/rstb.2019.0699
PMID:33308063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7741077/
Abstract

Mind-wandering has become a captivating topic for cognitive neuroscientists. By now, it is reasonably well described in terms of its phenomenology and the large-scale neural networks that support it. However, we know very little about what neurobiological mechanisms trigger a mind-wandering episode and sustain the mind-wandering brain state. Here, we focus on the role of ascending neuromodulatory systems (i.e. acetylcholine, noradrenaline, serotonin and dopamine) in shaping mind-wandering. We advance the hypothesis that the hippocampal sharp wave-ripple (SWR) is a compelling candidate for a brain state that can trigger mind-wandering episodes. This hippocampal rhythm, which occurs spontaneously in quiescent behavioural states, is capable of propagating widespread activity in the default network and is functionally associated with recollective, associative, imagination and simulation processes. The occurrence of the SWR is heavily dependent on hippocampal neuromodulatory tone. We describe how the interplay of neuromodulators may promote the hippocampal SWR and trigger mind-wandering episodes. We then identify the global neuromodulatory signatures that shape the evolution of the mind-wandering brain state. Under our proposed framework, mind-wandering emerges due to the interplay between neuromodulatory systems that influence the transitions between brain states, which either facilitate, or impede, a wandering mind. This article is part of the theme issue 'Offline perception: voluntary and spontaneous perceptual experiences without matching external stimulation'.

摘要

思维漫游已经成为认知神经科学家们一个极具吸引力的研究课题。目前,人们已经相当详细地描述了思维漫游的现象学和支持它的大规模神经网络。然而,我们对触发思维漫游事件和维持思维漫游大脑状态的神经生物学机制知之甚少。在这里,我们专注于上升性神经调质系统(即乙酰胆碱、去甲肾上腺素、血清素和多巴胺)在塑造思维漫游中的作用。我们提出了一个假设,即海马体尖波-涟漪(SWR)是一种引人注目的候选脑状态,可以引发思维漫游事件。这种在安静行为状态下自发出现的海马体节律能够在默认网络中传播广泛的活动,并与回忆、联想、想象和模拟过程具有功能关联。SWR 的发生高度依赖于海马体的神经调质。我们描述了神经调质的相互作用如何促进海马体 SWR 并引发思维漫游事件。然后,我们确定了塑造思维漫游大脑状态演变的全局神经调质特征。在我们提出的框架下,思维漫游是由于影响大脑状态之间转换的神经调质系统相互作用而产生的,这些转换要么促进,要么阻碍了漫游的思维。本文是主题为“离线感知:没有匹配外部刺激的自愿和自发的感知体验”的特刊的一部分。