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中国大陆流行犬细小病毒 2 型的特征描述的系统文献回顾和荟萃分析。

A systematic literature review and meta-analysis of characterization of canine parvoviruses 2 prevalent in mainland China.

机构信息

College of Life Science of Longyan University, Longyan, 364012, China.

Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan, 364012, China.

出版信息

Virol J. 2020 Dec 11;17(1):195. doi: 10.1186/s12985-020-01462-3.

DOI:10.1186/s12985-020-01462-3
PMID:33308261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7729692/
Abstract

BACKGROUND

Canine parvovirus 2 (CPV-2) is a pathogenic virus that infects dogs, causing a highly infectious disease. Monitoring CPV-2 spread is an important part of prevention; however, the prevalence and epidemiological characteristics of CPV-2 have not been systematically evaluated and analyzed in mainland China. Therefore, a systematic review and meta-analysis were performed to assess prevalence and epidemiological characteristics of CPV-2 in domestic dogs in mainland China.

METHODS

In this study, Chinese and English literature on CPV-2 epidemiology published between January 2006 and December 2019 was evaluated. Regarding meta-analysis, the random-effect model was employed by forest plot with 95% of confidence interval. The number of CPV-2 infections was identified and the pooled prevalence of infection, as well as the epidemiological characteristics, was calculated using meta-analysis.

RESULTS

A total of 39 studies (data from 137,844 dogs) met the evaluation criteria and were used in our study. The pooled prevalence of CPV-2 infection in mainland China was 36%. CPV-2 infection were associated with age, breed, sampling season and immunization status, but not with gender, publication time and diagnostic methods.

CONCLUSIONS

Our results indicated that CPV-2 is prevalent among dogs in China. It is therefore necessary to carry out continuous surveillance and epidemiological studies of CPV-2. In addition, accordingly, effective measures should be taken to prevent the transmission and spread of CPV-2 among the Chinese dog population.

摘要

背景

犬细小病毒 2 型（CPV-2）是一种感染犬的致病病毒，可引起高度传染性疾病。监测 CPV-2 的传播是预防的重要组成部分；然而，CPV-2 在中国大陆的流行情况和流行病学特征尚未得到系统评估和分析。因此，进行了系统评价和荟萃分析，以评估 CPV-2 在中国大陆的家养犬中的流行情况和流行病学特征。

方法

本研究评估了 2006 年 1 月至 2019 年 12 月期间发表的有关 CPV-2 流行病学的中文和英文文献。对于荟萃分析，采用森林图的随机效应模型，置信区间为 95%。通过荟萃分析确定 CPV-2 感染的数量，并计算感染的总感染率以及流行病学特征。

结果

共有 39 项研究（来自 137844 只狗的数据）符合评估标准并纳入本研究。中国大陆 CPV-2 感染的总感染率为 36%。CPV-2 感染与年龄、品种、采样季节和免疫状态有关，但与性别、发表时间和诊断方法无关。

结论

我们的结果表明 CPV-2 在我国犬中普遍流行。因此，有必要对 CPV-2 进行持续监测和流行病学研究。此外，应采取相应措施，防止 CPV-2 在我国犬群中的传播和扩散。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/490242b48114/12985_2020_1462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/3ed0ab18b98a/12985_2020_1462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/10003b53c7b7/12985_2020_1462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/490242b48114/12985_2020_1462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/3ed0ab18b98a/12985_2020_1462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/10003b53c7b7/12985_2020_1462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/7731465/490242b48114/12985_2020_1462_Fig3_HTML.jpg

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