Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China.
Chin J Nat Med. 2020 Nov;18(11):860-871. doi: 10.1016/S1875-5364(20)60029-2.
Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine (TCM) and in chemical medicine, as well as in cosmetic ingredients, nutraceuticals and food products. Isochlorogenic acid (ICGA), which has medicinal value, has been discovered in various plants. As a widespread natural medicine, ICGA should be the subject of further research and development. However, there have been no systematic analyses of ICGA. According to our investigation, ICGA was initially isolated from green coffee extracts by Barnes et al. in 1950. To date, it has been discovered in a variety of tea, vegetables, medicinal diet and TCM materials. ICGA is used as a chemical marker for the quality control of these TCM materials. The metabolic process of ICGA has been studied in detail, conforming to be linear dynamics. Thus, the clear pharmacokinetics of ICGA offers a solid foundation for its research and development. ICGA has multiple biological and pharmacological effects, and studies have mainly focused on its antioxidant, anti-inflammatory, antimicrobial, hypoglycemic, neuroprotective, and cardiovascular protective effects, and hepatoprotective properties. The mechanisms underlying these effects are summarized in this review to provide scientific support and inspiration for the future research and development of ICGA and ICGA-rich natural products.
天然产物作为中药和化学药物、化妆品成分、营养保健品和食品的重要资源，引起了广泛关注。具有药用价值的绿原酸（ICGA）已在多种植物中被发现。作为一种广泛应用的天然药物，ICGA应该成为进一步研究和开发的对象。然而，目前还没有对 ICGA 的系统分析。根据我们的调查，ICGA 最初是由 Barnes 等人于 1950 年从绿咖啡豆提取物中分离出来的。迄今为止，它已在各种茶、蔬菜、药食同源和中药材料中被发现。ICGA 被用作这些中药材料质量控制的化学标志物。ICGA 的代谢过程已经得到了详细研究，符合线性动力学。因此，ICGA 的明确药代动力学为其研究和开发提供了坚实的基础。ICGA 具有多种生物学和药理学作用，研究主要集中在其抗氧化、抗炎、抗菌、降血糖、神经保护和心血管保护作用以及保肝作用。本文综述了这些作用的机制，为 ICGA 和富含 ICGA 的天然产物的未来研究和开发提供了科学依据和启示。
