Liu Shuai, Xiong Yunxia, Cao Shuting, Wen Xiaolu, Xiao Hao, Li Yajing, Chi Lei, He Dongsheng, Jiang Zongyong, Wang Li
State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Key Laboratory of Animal Breeding and Nutrition, Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Zhucheng Haotian Pharmaceutical Co., Ltd., Zhucheng 262218, China.
Antioxidants (Basel). 2022 Oct 12;11(10):2016. doi: 10.3390/antiox11102016.
This study aimed to investigate the effects of diet supplementation with stevia residue extract (SRE) on growth performance, intestinal health, and antioxidant capacity of weaned piglets. A total of 144 weaned piglets (body weight 6.8 ± 0.5 kg) were randomly selected and allocated into four treatment groups with six replicates of six pigs/pen. The treatments consisted of a basal diet without SRE or basal diet supplemented with 100, 200, or 400 mg/kg SRE. The results showed that the addition of 200 mg/kg SRE to the diet significantly reduced (p < 0.05) the diarrhea rate of piglets compared with the control group. The supplementation of 400 mg/kg SRE in the diet significantly reduced the piglets’ serum MDA content and significantly increased (p < 0.05) the T-AOC, T-SOD, and GSH-PX activity in the serum. The dietary supplementation with 400 mg/kg SRE significantly increased (p < 0.05) the CAT and GSH-PX activity in the liver. Moreover, the supplementation of 400 mg/kg SRE in the diet significantly increased (p < 0.05) the relative abundance of Prevotellaceae (genus) and Roseburia (genus) beneficial bacteria compared to the control group. Spearman’s correlation analysis showed that Prevotella (genus) abundance was positively correlated with liver GSH-PX activity and acetic acid content of colon contents. In conclusion, the supplementation of 400 mg/kg SRE to the diet can improve piglet health by regulating antioxidant reduction homeostasis, which may also be associated with an increase in the relative numbers of potentially beneficial bacteria.
本研究旨在探讨日粮中添加甜叶菊残渣提取物（SRE）对断奶仔猪生长性能、肠道健康和抗氧化能力的影响。总共随机选取144头断奶仔猪（体重6.8±0.5千克），并将其分为四个处理组，每组六个重复，每个重复六头猪/栏。处理组包括不添加SRE的基础日粮或添加100、200或400毫克/千克SRE的基础日粮。结果表明，与对照组相比，日粮中添加200毫克/千克SRE显著降低（p<0.05）了仔猪的腹泻率。日粮中添加400毫克/千克SRE显著降低了仔猪血清丙二醛（MDA）含量，并显著提高（p<0.05）了血清中总抗氧化能力（T-AOC）、总超氧化物歧化酶（T-SOD）和谷胱甘肽过氧化物酶（GSH-PX）的活性。日粮中添加400毫克/千克SRE显著提高（p<0.05）了肝脏中过氧化氢酶（CAT）和GSH-PX的活性。此外，与对照组相比，日粮中添加400毫克/千克SRE显著提高（p<0.05）了普雷沃氏菌属和罗斯氏菌属有益菌的相对丰度。Spearman相关性分析表明，普雷沃氏菌属的丰度与肝脏GSH-PX活性和结肠内容物中乙酸含量呈正相关。总之，日粮中添加400毫克/千克SRE可通过调节抗氧化还原稳态来改善仔猪健康，这也可能与潜在有益菌相对数量的增加有关。
