从食物和饮料中摄入的锰与 2 型糖尿病风险降低有关。
Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes.
机构信息
Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita Shi, Osaka, 565-0871, Japan; Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Shalaby land, Minia, 61511, Egypt.
Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita Shi, Osaka, 565-0871, Japan.
出版信息
Maturitas. 2021 Jan;143:127-131. doi: 10.1016/j.maturitas.2020.10.009. Epub 2020 Oct 19.
BACKGROUND
Despite the hypoglycemic and antioxidant effects of manganese, only one recent Chinese study has investigated the association between dietary manganese intake and type 2 diabetes.
METHODS
We recruited 19,862 Japanese men and women in the Japan Collaborative Cohort Study. The participants completed a food frequency questionnaire at the baseline survey (1988 = 1990) and a diabetes history at both baseline and 5-year surveys. We calculated the odds ratios (95 % CIs) of the 5-year cumulative incidence of self-reported physician-diagnosed type 2 diabetes according to quartiles of dietary manganese intake.
RESULTS
Within the 5-year period, we confirmed 530 new cases of type 2 diabetes (263 in men and 267 in women) with a 5-year cumulative incidence of 2.7 % (3.6 % in men and 2.1 % in women). Higher manganese intake was inversely associated with the women's but not the men's cumulative risk of type 2 diabetes over the 5-year period. In a full model adjusted for the participants' characteristics, diabetes risk factors and a wide range of dietary variables, the multivariable odds ratios (95 %CIs) of type 2 diabetes across the increasing quartiles of manganese intake (Q1 to Q4) were 1.00, 0.97 (0.65, 1.43), 1.04 (0.67, 1.61) and 1.10 (0.64, 1.92), p-trend = 0.66 among men and 1.00, 0.74 (0.51, 1.06), 0.62 (0.41, 0.94) and 0.53 (0.31, 0.88), p-trend = 0.01 among women. The association was observed mainly for those with low iron intake in women, particularly premenopausal women.
CONCLUSION
Strong inverse associations between dietary manganese intake and risk of type 2 diabetes were observed in women but not men.
背景
尽管锰具有降血糖和抗氧化作用，但仅有一项最近的中国研究调查了饮食锰摄入量与 2 型糖尿病之间的关系。
方法
我们招募了日本协同队列研究中的 19862 名日本男性和女性。参与者在基线调查（1988 年=1990 年）时完成了食物频率问卷，并在基线和 5 年调查时报告了糖尿病史。我们根据饮食锰摄入量的四分位数计算了 5 年内自我报告的医生诊断的 2 型糖尿病的累积发生率的比值比（95%置信区间）。
结果
在 5 年内，我们共确认了 530 例新的 2 型糖尿病病例（男性 263 例，女性 267 例），5 年累积发病率为 2.7%（男性为 3.6%，女性为 2.1%）。较高的锰摄入量与女性但与男性 5 年内的 2 型糖尿病累积风险呈负相关。在调整参与者特征、糖尿病危险因素和广泛的饮食变量的全模型中，锰摄入量递增四分位数（Q1 到 Q4）的 2 型糖尿病的多变量比值比（95%置信区间）分别为 1.00、0.97（0.65，1.43）、1.04（0.67，1.61）和 1.10（0.64，1.92），男性的趋势检验 p 值=0.66；女性分别为 1.00、0.74（0.51，1.06）、0.62（0.41，0.94）和 0.53（0.31，0.88），趋势检验 p 值=0.01。这种关联主要见于女性中低铁摄入者，尤其是绝经前女性。
结论
饮食锰摄入量与 2 型糖尿病风险之间存在强烈的负相关，这种关联在女性中观察到，但在男性中未观察到。
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