Sánchez-Rodríguez Martha A, Castrejón-Delgado Lizett, Zacarías-Flores Mariano, Arronte-Rosales Alicia, Mendoza-Núñez Víctor Manuel
Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Av. Guelatao No. 66, Iztapalapa, CP 09230, México, D.F., México.
Hospital Gustavo Baz Prada, Instituto de Salud del Estado de México, Av. Adolfo López Mateos / Bordo Xochiaca S/N, Ciudad Nezahualcóyotl, CP 57300, Estado de México, México.
BMC Womens Health. 2017 Jan 3;17(1):1. doi: 10.1186/s12905-016-0358-7.
Menopause is the onset of aging in women. During this process, some women experience physical changes that may impact upon their psychological and social status, also affecting their quality of life. Furthermore, several psychological changes following menopause have been shown to act as pro-oxidant, but the association between the psychological status that modify the quality of life and oxidative stress in postmenopausal women is still unclear. The aim of this study was to determinate the relationship between oxidative stress with psychological disturbances, low self-esteem, depressive mood and anxiety, and quality of life in the postmenopausal women.
We carried out a cross-sectional study with101 premenopausal and 101 postmenopausal women from Mexico City. As markers of oxidative stress we measured plasma lipoperoxide levels, erythrocyte superoxide dismutase and glutathione peroxidase activities, and total antioxidant status. We calculate a stress score as global oxidative stress status, with cut-off values for each parameter; this score range from 0 to 6, representing the severity of markers modifications. All the women were rated using the Coopersmith Self-Esteem Inventory, the Zung Self-Rating Anxiety and the Zung Self-Rating Depression Scales, and the WHO Quality of Life-brief.
The postmenopausal women with low quality of life in the WHO Quality of Life-brief and their subscales had higher stress score compared with premenopausal women with high quality of life (p < 0.05). We found a positive correlation among lipoperoxide levels and Zung Self-Rating Anxiety and Zung Self-Rating Depression score (r = 0.226 and r = 0.173, respectively, p < 0.05), and a negative correlation with WHO Quality of Life-brief scores (r = -0.266, p < 0.01) in postmenopausal women. Multiple linear regression analysis revealed that average lipoperoxide levels increase by 0.0007 μmol/L for every 1-point increase in the Coopersmith Self-Esteem Inventory and by 0.001 μmol/L for every 1-point decrease in the WHO Quality of Life-brief, after adjusted for pro-oxidant factors. Zung Self-Rating Anxiety and Zung Self-Rating Depression Scales scores also contribute to increase lipoperoxides levels, but not significant.
Our findings suggest that oxidative stress is increased in postmenopausal women with psychological disturbances and low quality of life.
绝经是女性衰老的开始。在此过程中，一些女性会经历身体变化，这可能会影响她们的心理和社会状态，进而影响她们的生活质量。此外，已有研究表明绝经后的一些心理变化具有促氧化作用，但绝经后女性中影响生活质量的心理状态与氧化应激之间的关联仍不明确。本研究的目的是确定氧化应激与绝经后女性的心理障碍、自卑、抑郁情绪和焦虑以及生活质量之间的关系。
我们对来自墨西哥城的101名绝经前女性和101名绝经后女性进行了一项横断面研究。作为氧化应激的标志物，我们测量了血浆脂过氧化物水平、红细胞超氧化物歧化酶和谷胱甘肽过氧化物酶活性以及总抗氧化状态。我们计算了一个应激评分作为整体氧化应激状态，每个参数都有临界值；该评分范围为0至6，代表标志物改变的严重程度。所有女性均使用库珀史密斯自尊量表、zung自评焦虑量表、zung自评抑郁量表以及世界卫生组织生活质量简表进行评分。
在世界卫生组织生活质量简表及其子量表中生活质量较低的绝经后女性，与生活质量较高的绝经前女性相比，应激评分更高（p<0.05）。我们发现绝经后女性的脂过氧化物水平与zung自评焦虑量表和zung自评抑郁量表评分呈正相关（r分别为0.226和0.173，p<0.05），与世界卫生组织生活质量简表评分呈负相关（r=-0.266，p<0.01）。多元线性回归分析显示，在调整促氧化因素后，库珀史密斯自尊量表每增加1分，平均脂过氧化物水平升高0.0007μmol/L，世界卫生组织生活质量简表每降低1分，平均脂过氧化物水平升高0.001μmol/L。zung自评焦虑量表和zung自评抑郁量表评分也会导致脂过氧化物水平升高，但不显著。
我们的研究结果表明，心理障碍和生活质量较低的绝经后女性氧化应激增加。
