Gynecology Department, Cliniques universitaires St-Luc, Brussels, Belgium; Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
Prof. Em. Catholic University of Louvain, Brussels, Belgium; Société de Recherche pour l'Infertilité (SRI), Brussels, Belgium.
Trends Mol Med. 2021 Aug;27(8):777-791. doi: 10.1016/j.molmed.2020.11.003. Epub 2020 Dec 9.
Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility in prepubertal girls and young women who require immediate chemotherapy. Ovarian tissue transplantation has been shown to restore hormonal cycles and fertility, but a large proportion of the follicle reserve is lost as a consequence of exposure to hypoxia. Another crucial concern is the risk of reimplanting malignant cells together with the grafted tissue. In this review, the authors advance some challenging propositions, from prevention of chemotherapy-related gonadotoxicity to ovarian tissue cryopreservation and transplantation, including the artificial ovary approach.
癌症治疗方法日益有效，但可能导致医源性卵巢早衰。卵巢组织冷冻保存是唯一可选择的方法，用于保护需要立即接受化疗的青春期前女孩和年轻女性的生育能力。卵巢组织移植已被证明可以恢复激素周期和生育能力，但由于缺氧暴露，卵泡储备的很大一部分会丢失。另一个关键问题是与移植组织一起重新植入恶性细胞的风险。在这篇综述中，作者提出了一些具有挑战性的建议，从预防化疗相关的性腺毒性到卵巢组织冷冻保存和移植，包括人工卵巢方法。
