O'Connor D T, Strause L, Saltman P, Parmer R J, Cervenka J
Department of Medicine, University of California, San Diego.
J Clin Hypertens. 1987 Dec;3(4):405-8.
Captopril, a sulfhydryl compound that lowers blood pressure by inhibiting the zinc metalloenzyme, angiotensin converting enzyme, may occasionally result in ageusia, a symptom also associated with zinc deficiency. We therefore studied serum zinc and copper concentrations in a group of 14 essential hypertensive subjects before treatment and after 5-6 months of antihypertensive oral monotherapy with either captopril (50 mg, twice daily; n = 7) or other drugs (propranolol or alphamethyldopa; n = 7). Serum zinc and copper were unaltered by either regimen. Thus, zinc depletion is an unlikely consequence of long-term exposure to captopril, at least in the dosages commonly used for treatment of hypertension.
卡托普利是一种巯基化合物，通过抑制锌金属酶——血管紧张素转换酶来降低血压，它偶尔可能导致味觉丧失，这也是一种与锌缺乏相关的症状。因此，我们对一组14名原发性高血压患者进行了研究，在治疗前以及使用卡托普利（50毫克，每日两次；n = 7）或其他药物（普萘洛尔或甲基多巴；n = 7）进行5至6个月的口服抗高血压单一疗法后，检测他们血清锌和铜的浓度。两种治疗方案均未改变血清锌和铜的水平。因此，长期接触卡托普利不太可能导致锌缺乏，至少在常用于治疗高血压的剂量下是这样。
