Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, People's Republic of China.
Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, People's Republic of China; Department of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, New York.
Ann Allergy Asthma Immunol. 2021 Jun;126(6):639-654. doi: 10.1016/j.anai.2020.12.002. Epub 2020 Dec 10.
To summarize the recent evidence of traditional Chinese medicine (TCM) for food allergy and eczema.
Published literature from PubMed database and abstract conference presentations.
Studies relevant to TCM for food allergy and eczema were included.
TCM is the main component of complementary and alternative medicine in the United States. Food Allergy Herbal Formula 2 (FAHF-2) (derived from the classical formula Wu Mei Wan) prevented systemic anaphylaxis in murine models and was found to have safety and preliminary immunomodulatory effects on T cells and basophils. The phase II trial of combined TCM with oral immunotherapy and omalizumab for multiple food allergy is ongoing. Retrospective practice-based evidence study revealed that comprehensive TCM therapy effectively prevented frequent and severe food anaphylaxis triggered by skin contact or protein inhalation. The traditional Japanese herbal medicine Kakkonto suppressed allergic diarrhea and decreased mast cells in intestinal mucosa in a murine model. The active compounds from TCM were found to have potent inhibition of immunoglobulin (Ig) E, mast cell activation, and proinflammatory cytokine or signaling pathway (tumor necrosis factor alpha, interleukin 8, NF-κB) suggesting value for both IgE and non-IgE-mediated food allergy. Triple TCM therapy including ingestion, bath, and cream markedly improved skin lesion, itching, and sleep loss in patients with corticosteroid dependent, recalcitrant, or topical steroid withdrawal. Xiao Feng San and Japanese and Korean formulas were found to have effectiveness in eczema. Furthermore, acupuncture reduced wheal size, skin itching, and basophil activation in atopic dermatitis. Moreover, TCM is generally safe.
TCM has potential as safe and effective therapy for food allergy and eczema. Further research is needed for botanical drug development and to further define the mechanisms of actions.
FAHF-2: https://ichgcp.net/clinical-trials-registry/NCT00602160; ethyl acetate and butanol purified FAHF-2: https://clinicaltrials.gov/ct2/show/NCT02879006.
总结中医药治疗食物过敏和湿疹的最新证据。
PubMed 数据库和会议摘要中的已发表文献。
纳入与中医药治疗食物过敏和湿疹相关的研究。
中医药是美国补充和替代医学的主要组成部分。食物过敏草药配方 2（FAHF-2）（源自经典方剂乌梅丸）可预防小鼠模型中的全身性过敏反应，并且已被发现对 T 细胞和嗜碱性粒细胞具有安全性和初步的免疫调节作用。正在进行联合中医药、口服免疫疗法和奥马珠单抗治疗多种食物过敏的 II 期试验。基于实践的回顾性证据研究表明，综合中医药治疗可有效预防皮肤接触或蛋白吸入引发的频繁和严重食物过敏反应。传统的日本草药和汉方 Kakkonto 抑制了小鼠模型中的过敏性腹泻和肠黏膜中的肥大细胞。从中医药中提取的活性化合物具有很强的抑制免疫球蛋白（Ig）E、肥大细胞活化以及促炎细胞因子或信号通路（肿瘤坏死因子-α、白细胞介素 8、NF-κB）的作用，提示其对 IgE 和非 IgE 介导的食物过敏均有治疗价值。包括口服、沐浴和乳膏在内的三重中医药疗法显著改善了依赖皮质类固醇、难治性或局部皮质类固醇撤退的患者的皮肤损伤、瘙痒和睡眠缺失。小枫散和日本、韩国的方剂被证明对湿疹有效。此外，针灸可减少特应性皮炎患者的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医药通常是安全的。
中医药作为治疗食物过敏和湿疹的安全有效疗法具有潜力。需要进一步研究植物药的开发，并进一步明确作用机制。
FAHF-2：https://ichgcp.net/clinical-trials-registry/NCT00602160；乙酸乙酯和正丁醇纯化的 FAHF-2：https://clinicaltrials.gov/ct2/show/NCT02879006。
