Yamamoto-Furusho Jesús K, Sánchez-Morales Germán E
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico.
Inflamm Intest Dis. 2020 Nov;5(4):200-204. doi: 10.1159/000510070. Epub 2020 Oct 14.
Ulcerative colitis (UC) is a subtype of inflammatory bowel disease that can develop extraintestinal manifestations (EIMs) in a subgroup of patients. The aim of this work was to study the frequency and clinical factors associated with the development of EIMs.
We evaluated a total of 260 Mexican patients with confirmed UC who were followed retrospectively in order to identify the factors associated with the presence of EIMs.
The frequency of EIM was 55.8%. The factors associated with the development of EIM were pancolitis ( = 0.003, OR = 2.44, 95% CI = 1.34-4.56) and previous colectomy ( = 0.024, OR = 7.54, 95% CI = 1.20-60.44). A clinical course of initial activity and then long remission for >5 years was found to be a protective factor ( = 0.002, OR = 0.31, 95% CI = 0.14-0.67).
The frequency of EIM was 55.8% in our population, and the factors associated with their development were pancolitis and colectomy; meanwhile, a clinical course of initial activity and then long remission was a protector feature.
溃疡性结肠炎（UC）是炎症性肠病的一种亚型，部分患者会出现肠外表现（EIMs）。本研究旨在探讨EIMs发生的频率及相关临床因素。
我们评估了260例确诊为UC的墨西哥患者，对其进行回顾性随访，以确定与EIMs存在相关的因素。
EIMs的发生率为55.8%。与EIMs发生相关的因素为全结肠炎（P = 0.003，OR = 2.44，95%CI = 1.34 - 4.56）和既往结肠切除术（P = 0.024，OR = 7.54，95%CI = 1.20 - 60.44）。发现初始活动期后长期缓解超过5年的临床病程是一个保护因素（P = 0.002，OR = 0.31，95%CI = 0.14 - 0.67）。
在我们的研究人群中，EIMs的发生率为55.8%，其发生相关因素为全结肠炎和结肠切除术；同时，初始活动期后长期缓解的临床病程是一个保护特征。
