Miles M R, Olsen L, Rogers A
JAMA. 1977 Oct 24;238(17):1836-7. doi: 10.1001/jama.238.17.1836.
To test the hypothesis that all cases of vaginal candidiasis are associated with a "reservoir" of this organism in the bowel, paired specimens of feces and vaginal material were cultured for Candida albicans simultaneously. Ninety-eight young women who complained of recurrent vaginitis were selected in sequence. The results showed that if C albicans was cultured from the vagina, it was always found in the stool. Conversely, if it was not isolated from the stool, it was never found in the vagina. These data are presented as an explanation for the recurrent nature of Candida vaginitis, and thus a cure of vaginitis would not be possible without prior eradication of C albicans from the gut. The gut-reservoir concept may well apply to other forms of candidiasis.
为了验证所有阴道念珠菌病病例均与肠道中该生物体的“储存库”相关这一假设，同时对粪便和阴道分泌物的配对样本进行白色念珠菌培养。依次选取了98名主诉复发性阴道炎的年轻女性。结果显示，如果从阴道中培养出白色念珠菌，那么在粪便中总能发现它。相反，如果在粪便中未分离出白色念珠菌，那么在阴道中也从未发现过。这些数据被作为念珠菌性阴道炎复发性质的一种解释，因此，如果不先从肠道中根除白色念珠菌，阴道炎就无法治愈。肠道储存库的概念很可能适用于其他形式的念珠菌病。
