Bokma Jade, Gille Linde, De Bleecker Koen, Callens Jozefien, Haesebrouck Freddy, Pardon Bart, Boyen Filip
Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Antibiotics (Basel). 2020 Dec 9;9(12):882. doi: 10.3390/antibiotics9120882.
is an important pathogen causing mostly pneumonia in calves and mastitis in dairy cattle. In the absence of an effective vaccine, antimicrobial therapy remains the main control measure. Antimicrobial use in veal calves is substantially higher than in conventional herds, but whether veal calves also harbor more resistant strains is currently unknown. Therefore, we compared antimicrobial susceptibility test results of isolates from different cattle sectors and genomic clusters. The minimum inhibitory concentration of nine antimicrobials was determined for 141 Belgian isolates (29 dairy, 69 beef, 12 mixed, 31 veal farms), and was used to estimate the epidemiological cut-off. Acquired resistance was frequently observed for the macrolides, while no acquired resistance to oxytetracycline and doxycycline, minimal acquired resistance to florfenicol and tiamulin, and a limited acquired resistance to enrofloxacin was seen. isolates from beef cattle or genomic cluster III had higher odds of being gamithromycin-resistant than those from dairy cattle or genomic clusters IV and V. In this study, no cattle industry could be identified as source of resistant strains. A single guideline for antimicrobial use for infections, with a small remark for gamithromycin, is likely sufficient.
是一种重要的病原体，主要导致犊牛肺炎和奶牛乳腺炎。在缺乏有效疫苗的情况下，抗菌治疗仍然是主要的控制措施。犊牛的抗菌药物使用量明显高于传统牛群，但目前尚不清楚犊牛是否也携带更多耐药菌株。因此，我们比较了来自不同牛群部门和基因组簇的分离株的药敏试验结果。测定了来自141个比利时分离株（29个奶牛场、69个肉牛场、12个混合场、31个犊牛场）的9种抗菌药物的最低抑菌浓度，并用于估计流行病学临界值。大环内酯类药物经常出现获得性耐药，而对土霉素和强力霉素未观察到获得性耐药，对氟苯尼考和替米考星的获得性耐药最小，对恩诺沙星的获得性耐药有限。来自肉牛或基因组簇III的分离株对加米霉素耐药的几率高于来自奶牛或基因组簇IV和V的分离株。在本研究中，无法确定任何一个养牛行业是耐药菌株的来源。针对感染制定单一的抗菌药物使用指南，并对加米霉素作少量说明可能就足够了。
