Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
J Vet Intern Med. 2022 Mar;36(2):820-828. doi: 10.1111/jvim.16348. Epub 2022 Jan 7.
Respiratory infections are the main indication for antimicrobial use in calves. Optimal treatment duration currently is unknown, but shorter duration would likely decrease selection for antimicrobial resistance.
HYPOTHESIS/OBJECTIVES: Determine differences in cure rate and healing time between animals treated with florfenicol and oxytetracycline in a natural outbreak of respiratory disease using reaeration observed on thoracic ultrasound examination as healing criterion.
Commercial farm housing 130, 3 to 9 month old Belgian blue beef calves.
Randomized clinical trial during an outbreak of respiratory disease. Metaphylactic treatment was initiated, randomly treating animals with either florfenicol or oxytetracycline. Ultrasonographic follow-up was done the first day and every other day for a 14-day period. At the individual animal level, treatment was discontinued when reaeration of the lungs occurred. Differences in cure rate and healing time were determined.
Of the 130 animals studied, 67.7% developed a lung consolidation ≥0.5 cm. The mean ultrasonographic healing time was 2.5 days in the florfenicol group compared to 3.1 days in the oxytetracycline group (P = .04). After single treatment, 80.6% and 60.3% had no consolidations in the florfenicol and oxytetracycline groups, respectively (P = .01). A Mycoplasma bovis strain was genetically and phenotypically determined to be susceptible to both antimicrobials.
Ultrasonographic lung reaeration shows potential as a cure criterion to rationalize antimicrobial use for outbreaks of pneumonia. In our study, florfenicol resulted in a faster cure and higher reduction in antimicrobial usage than did oxytetracycline.
呼吸道感染是犊牛使用抗生素的主要指征。目前尚不清楚最佳治疗持续时间，但较短的疗程可能会减少对抗菌药物耐药性的选择。
假设/目的：使用胸腔超声检查观察到的再充气作为愈合标准，确定在使用氟苯尼考和土霉素治疗因再充气而出现的自然爆发性呼吸道疾病时，动物的治愈率和愈合时间的差异。
一家拥有 130 头 3 至 9 月龄比利时蓝牛肉犊牛的商业农场。
在呼吸道疾病爆发期间进行随机临床试验。开始进行预防治疗，随机用氟苯尼考或土霉素治疗动物。在 14 天的时间里，每天进行一次超声检查。在个体动物水平上，当肺部重新充气时停止治疗。确定治愈率和愈合时间的差异。
在研究的 130 头动物中，67.7%的动物出现了≥0.5 厘米的肺实变。氟苯尼考组的平均超声愈合时间为 2.5 天，而土霉素组为 3.1 天（P=0.04）。单次治疗后，氟苯尼考组和土霉素组分别有 80.6%和 60.3%的动物没有肺实变（P=0.01）。一种牛支原体菌株在遗传和表型上被确定对两种抗生素均敏感。
超声肺部再充气显示出作为一种治疗标准的潜力，可以合理使用抗生素治疗肺炎爆发。在我们的研究中，氟苯尼考比土霉素更快地治愈并减少了抗生素的使用。
