Heidelberg Institute of Global Health, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Institute of Social Medicine and Epidemiology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
Int J Environ Res Public Health. 2020 Dec 9;17(24):9215. doi: 10.3390/ijerph17249215.
Previous studies have shown that the incidence of gastric cancer (GC), and particularly intestinal GC, is higher among resettlers from the former Soviet Union (FSU) than in the general German population. Our aim was to investigate if the higher risk remains over time.
GC cases between 1994 and 2013, in a cohort of 32,972 resettlers, were identified by the respective federal cancer registry. Age-standardized rates (ASRs) and standardized incidence ratios (SIRs) were analyzed in comparison to the general population for GC subtypes according to the Laurén classification. Additionally, the cohort was pooled with data from a second resettler cohort from Saarland to investigate time trends using negative binomial regression.
The incidence of intestinal GC was elevated among resettlers in comparison to the general population (SIR (men) 1.64, 95% CI: 1.09-2.37; SIR (women) 1.91, 95% CI: 1.15-2.98). The analysis with the pooled data confirmed an elevated SIR, which was stable over time.
Resettlers' higher risk of developing intestinal GC does not attenuate towards the incidence in the general German population. Dietary and lifestyle patterns might amplify the risk of GC, and we believe that further investigation of risk behaviors is needed to better understand the development of disease pattern among migrants.
先前的研究表明，在前苏联（FSU）移民中，胃癌（GC）的发病率，尤其是肠型胃癌的发病率高于一般德国人群。我们的目的是研究这种较高的风险是否会随时间而持续存在。
通过各自的联邦癌症登记处，确定了 1994 年至 2013 年间 32972 名移民队列中的 GC 病例。根据 Lauren 分类，将 GC 亚型与一般人群进行比较，分析年龄标准化率（ASR）和标准化发病比（SIR）。此外，将该队列与来自萨尔州的第二个移民队列的数据进行合并，以使用负二项式回归研究时间趋势。
与一般人群相比，移民中肠型 GC 的发病率升高（男性 SIR（1.64，95%CI：1.09-2.37）；女性 SIR（1.91，95%CI：1.15-2.98））。使用合并数据的分析证实了 SIR 升高，且随时间保持稳定。
移民中肠型 GC 的发病风险不会随着德国一般人群的发病率而降低。饮食和生活方式可能会放大 GC 的风险，我们认为需要进一步调查风险行为，以更好地了解移民中疾病模式的发展。
