Markeeva-Ilisevic Evgenia, Holleczek Bernd, Becher Heiko, Winkler Volker
Medical Faculty of Heidelberg, Heidelberg, Germany.
Saarland cancer registry, Saarbrücken, Germany.
Arch Public Health. 2022 Mar 18;80(1):85. doi: 10.1186/s13690-022-00842-1.
UV radiation is a significant risk factor for non-melanoma skin cancer (NMSC). Ethnic Germans (resettlers) who immigrated to Germany from the former Soviet Union may have had a relatively high UV light exposure and thus a higher risk of developing NMSC. We compared the incidence of NMSC in a resettler cohort with the general population of the Saarland (Federal state of Germany) in relation to tumour location.
All new NMSC cases (resettler cohort and total population) between 1990 and 2007 were retrieved from the Saarland cancer registry and classified according to sex, histology, and location. The classification used for tumour location approximated the previous UV exposure. Age-standardized incidence rates (ASR) for the general population and standardized incidence ratios (SIR) for resettlers compared to the general population were calculated and modelled using Poisson regression.
Sex-specific overall SIR indicated a significant increase in female resettlers (SIR 1.31 (95% CI 1.02-1.67)) which can mostly be attributed to an increased incidence of squamous cell carcinoma. The regression analysis showed that among resettlers the risk of developing tumours in UV-exposed skin areas was 2.16 (95% CI 1.35-3.45) higher compared to the general population.
Female resettlers have a higher risk to be diagnosed with NMSC than the general German population. Based on the observed distribution of tumour location, it is suspected that UV exposure contributed significantly to this risk.
紫外线辐射是非黑色素瘤皮肤癌（NMSC）的一个重要风险因素。从前苏联移民到德国的德裔（重新定居者）可能有相对较高的紫外线暴露，因此患NMSC的风险更高。我们比较了重新定居者队列中NMSC的发病率与德国萨尔州（联邦州）普通人群的发病率，并分析了肿瘤位置。
从萨尔州癌症登记处检索了1990年至2007年间所有新的NMSC病例（重新定居者队列和总人口），并根据性别、组织学和位置进行分类。用于肿瘤位置的分类近似于先前的紫外线暴露情况。计算了普通人群的年龄标准化发病率（ASR）以及重新定居者与普通人群相比的标准化发病率比（SIR），并使用泊松回归进行建模。
特定性别的总体SIR表明女性重新定居者的发病率显著增加（SIR 1.31（95%CI 1.02 - 1.67）），这主要归因于鳞状细胞癌发病率的增加。回归分析表明，与普通人群相比，重新定居者中紫外线暴露皮肤区域发生肿瘤的风险高2.16倍（95%CI 1.35 - 3.45）。
女性重新定居者被诊断患有NMSC的风险高于德国普通人群。根据观察到的肿瘤位置分布，怀疑紫外线暴露是导致这种风险的重要因素。
