基于质子磁共振波谱分析的心肌缺血再灌注损伤大鼠不同脑区神经化学变化。
Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis.
机构信息
Department of Gastrointestinal Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
The Clinical Medical Research Center of Peritoneal Cancer of Wuhan, Clinical Cancer Study Center of Hubei Province, Key Laboratory of Tumor Biological Behavior of Hubei Province, Wuhan, China.
出版信息
Aging (Albany NY). 2020 Dec 14;13(2):2294-2309. doi: 10.18632/aging.202250.
BACKGROUND
Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown.
METHODS
Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS).
RESULTS
Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem.
CONCLUSIONS
Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These results provide preliminary evidence for understanding the cerebral metabolic process underlying myocardial ischemia-reperfusion injury in rats.
背景
最近的研究表明，心脏和大脑之间存在着复杂而动态的神经串扰。已经描述了关于心脏缺血的心脏-大脑相互作用，但涉及的大脑代谢机制尚不清楚。
方法
雄性 Sprague Dawley 大鼠被随机分为 2 组：接受心肌缺血再灌注手术的组（IR 组，n =10）和手术对照组（Con 组，n=10）。使用质子磁共振波谱（PMRS）评估不同脑区的代谢异常模式。
结果
超声心动图评估的结果显示，心脏缺血再灌注后出现心功能障碍。与对照组相比，IR 组的变化代谢物为牛磺酸和胆碱，差异主要发生在丘脑和脑干。
结论
大脑牛磺酸和胆碱的改变是重要的发现，为探索心肌缺血再灌注损伤的神经保护策略提供了新的途径。这些结果为理解大鼠心肌缺血再灌注损伤的脑代谢过程提供了初步证据。
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