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Disordered structure and flexible roles: using the prion protein N1 fragment for neuroprotective and regenerative therapy.

作者信息

Mohammadi Behnam, Glatzel Markus, Altmeppen Hermann Clemens

机构信息

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

出版信息

Neural Regen Res. 2021 Jul;16(7):1431-1432. doi: 10.4103/1673-5374.301008.

DOI:10.4103/1673-5374.301008
PMID:33318441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8284303/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abf/8284303/e09841c277fc/NRR-16-1431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abf/8284303/e09841c277fc/NRR-16-1431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abf/8284303/e09841c277fc/NRR-16-1431-g001.jpg

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Neural Regen Res. 2021 Jul;16(7):1431-1432. doi: 10.4103/1673-5374.301008.
2
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation.转染表达紊乱的朊病毒蛋白 N1 片段在小鼠中不能防止神经退行性疾病是由于内质网易位受损。
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Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.朊蛋白家族成员沙杜蛋白的表达会导致药物超敏反应，而野生型朊蛋白的共表达可减轻这种反应。
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Identification of prion protein-derived peptides of potential use in Alzheimer's disease therapy.鉴定朊病毒蛋白衍生肽，其具有用于阿尔茨海默病治疗的潜力。
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本文引用的文献

1
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation.转染表达紊乱的朊病毒蛋白 N1 片段在小鼠中不能防止神经退行性疾病是由于内质网易位受损。
Mol Neurobiol. 2020 Jun;57(6):2812-2829. doi: 10.1007/s12035-020-01917-2. Epub 2020 May 4.
2
Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells.朊病毒蛋白 N1 裂解肽刺激小胶质细胞与周围细胞的相互作用。
Sci Rep. 2020 Apr 20;10(1):6654. doi: 10.1038/s41598-020-63472-z.
3
Antisense oligonucleotides extend survival of prion-infected mice.
反义寡核苷酸延长朊病毒感染小鼠的存活时间。
JCI Insight. 2019 Jul 30;5(16):131175. doi: 10.1172/jci.insight.131175.
4
Identification of prion protein-derived peptides of potential use in Alzheimer's disease therapy.鉴定朊病毒蛋白衍生肽，其具有用于阿尔茨海默病治疗的潜力。
Biochim Biophys Acta Mol Basis Dis. 2018 Jun;1864(6 Pt A):2143-2153. doi: 10.1016/j.bbadis.2018.03.023. Epub 2018 Mar 28.
5
Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression.朊病毒蛋白裂解片段通过氧化还原调节线粒体分裂和 SOD2 表达来调控成年神经干细胞静止。
Cell Mol Life Sci. 2018 Sep;75(17):3231-3249. doi: 10.1007/s00018-018-2790-3. Epub 2018 Mar 24.
6
The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins.Sec61/SecY 复合物在内在无序蛋白易位方面固有缺陷。
J Biol Chem. 2017 Dec 29;292(52):21383-21396. doi: 10.1074/jbc.M117.788067. Epub 2017 Oct 30.
7
Diverse functions of the prion protein - Does proteolytic processing hold the key?朊病毒蛋白的多种功能 - 蛋白水解加工是否是关键？
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2128-2137. doi: 10.1016/j.bbamcr.2017.06.022. Epub 2017 Jul 8.
8
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.朊病毒蛋白是G蛋白偶联受体Adgrg6的激动剂配体。
Nature. 2016 Aug 25;536(7617):464-8. doi: 10.1038/nature19312. Epub 2016 Aug 8.
9
Aβ induces its own prion protein N-terminal fragment (PrPN1)-mediated neutralization in amorphous aggregates.淀粉样β蛋白（Aβ）在无定形聚集体中诱导其自身的朊病毒蛋白N端片段（PrPN1）介导的中和作用。
Neurobiol Aging. 2014 Jul;35(7):1537-48. doi: 10.1016/j.neurobiolaging.2014.02.001. Epub 2014 Feb 6.
10
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.朊病毒蛋白的 N 端片段与淀粉样β寡聚物结合，并在体内抑制其神经毒性。
J Biol Chem. 2013 Mar 15;288(11):7857-7866. doi: 10.1074/jbc.M112.423954. Epub 2013 Jan 28.