Ramchoun Mhamed, Khouya Tarik, Alibrahim Eid Alabed, Hmidani Abdelbassat, Sellam Khalid, Amrani Souliman, Harnafi Hicham, Benlyas Mohamed, Kasbi Chadli Fatima, Ouguerram Khadija, Alem Chakib
Laboratory of Biotechnology and Sustainable Development of Natural Resources, Polydisciplinary Faculty, University Sultan Moulay Slimane, Beni Mellal, Morocco.
Biochemistry and Natural Substances Team, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, Errachidia, Morocco.
Arch Physiol Biochem. 2023 Jun;129(3):618-625. doi: 10.1080/13813455.2020.1854308. Epub 2020 Dec 15.
has been reported to have significant hypolipidaemic effect in animal models. However, the mechanism of this hypolipidaemic action still unknown.
To determinate the possible mechanism(s) of hypolipidaemic action of a polyphenol-rich extract (PRE).
Plasma, faecal, and liver cholesterol, bile acid content in the faeces, and gene expression level of HMG-CoA reductase, CYP7A1, ABCG5 and ABCG8 were analysed after 9 weeks in hamsters feeding normal diet, high-fat diet (HFD) or HFD supplemented with 400 mg/kg body weight/day of PRE.
PRE significantly decreased total cholesterol content ( < .05) and HMG-CoA reductase expression ( < .05), but did not affect the faecal cholesterol, bile acid contents and CYP7A1 and ABCG5/G8 expression ( > .05).
We can conclude that the extract is efficient in the alleviation of chronic hyperlipidaemia by acting as cholesterol biosynthesis inhibitor.
据报道，其在动物模型中具有显著的降血脂作用。然而，这种降血脂作用的机制仍不清楚。
确定富含多酚的提取物（PRE）降血脂作用的可能机制。
在仓鼠分别喂食正常饮食、高脂饮食（HFD）或补充400mg/kg体重/天PRE的HFD 9周后，分析血浆、粪便和肝脏中的胆固醇、粪便中的胆汁酸含量以及HMG-CoA还原酶、CYP7A1、ABCG5和ABCG8的基因表达水平。
PRE显著降低了总胆固醇含量（P<0.05）和HMG-CoA还原酶表达（P<0.05），但不影响粪便胆固醇、胆汁酸含量以及CYP7A1和ABCG5/G8表达（P>0.05）。
我们可以得出结论，该提取物通过作为胆固醇生物合成抑制剂，在缓解慢性高脂血症方面是有效的。
