Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco.
Laboratory of Biotechnology and Sustainable Development of Natural Resources, Polydisciplinary Faculty, University Sultan Moulay Slimane, Beni Mellal, Morocco.
J Food Biochem. 2022 Sep;46(9):e14225. doi: 10.1111/jfbc.14225. Epub 2022 May 16.
Thymus atlanticus has been used by Moroccan people to treat a variety of health problems, particularly metabolic disorders. In this study, hamsters fed a high-fat diet daily received distilled water (a positive control) or a single dose of Thymus atlanticus polyphenols (Pp) for 63 days. The negative control was fed a normal diet and received distilled water. Results showed that the supplementation of HFD with Pp significantly (p < .001) reduced the levels of MDA and LDL cholesterol, restored insulin level, and increased the activities of serum paraoxonase-1 and HDL cholesterol levels, but did not affect (p > .05) the activity of superoxide dismutase and glutathione peroxidase when compared with the group feeding HFD alone. Thymus atlanticus could be an effective agent against dyslipidemia, oxidative stress, and insulin resistance. PRACTICAL APPLICATIONS: HFD consumption is a risk factor for oxidative stress and the development of metabolic disorders, such as hyperlipidemia and insulin resistance, which may result in atherosclerosis and related cardiovascular diseases, the leading causes of death globally. The management of these alterations is an important strategy to prevent and treat heart complications. Our results showed thatT. atlanticus effectively alleviated HFD-induced hyperlipidemia and insulin resistance and improved PON1 activity. T. atlanticus is a source of biomolecules that may be an effective supplement for controlling HFD-related metabolic disorders. Therefore, the findings of this study may be helpful in the preparation of effective supplements from T. atlanticus to control metabolic disorders and related complications.
大西洋百里香已被摩洛哥人民用于治疗多种健康问题，特别是代谢紊乱。在这项研究中，每天喂食高脂肪饮食的仓鼠接受蒸馏水（阳性对照）或单次剂量的大西洋百里香多酚（Pp）63 天。阴性对照组喂食正常饮食并接受蒸馏水。结果表明，HFD 补充 Pp 可显著（p<.001）降低 MDA 和 LDL 胆固醇水平，恢复胰岛素水平，并增加血清对氧磷酶-1 和 HDL 胆固醇水平的活性，但与单独喂食 HFD 的组相比，对超氧化物歧化酶和谷胱甘肽过氧化物酶的活性没有影响（p>.05）。大西洋百里香可能是对抗血脂异常、氧化应激和胰岛素抵抗的有效药物。实际应用：HFD 的摄入是氧化应激和代谢紊乱发展的一个风险因素，如高脂血症和胰岛素抵抗，这可能导致动脉粥样硬化和相关心血管疾病，这是全球死亡的主要原因。这些改变的管理是预防和治疗心脏并发症的重要策略。我们的结果表明，T. atlanticus 有效缓解了 HFD 诱导的高脂血症和胰岛素抵抗，并提高了 PON1 活性。T. atlanticus 是生物分子的来源，可能是控制 HFD 相关代谢紊乱的有效补充剂。因此，这项研究的结果可能有助于从 T. atlanticus 中制备有效的补充剂来控制代谢紊乱和相关并发症。
