Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Molecules. 2020 Dec 13;25(24):5905. doi: 10.3390/molecules25245905.
COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported in various epidemiological studies. Therefore, this review provides information and summarizes the juncture of antiviral, immunomodulatory, and hepatoprotective nutraceuticals that can be useful during the management of COVID-19.
COVID-19 被认为是本世纪最致命的大流行病之一。这种致命病毒以令人难以置信的速度迅速传播,令全球震惊,对全球科学界和医学界构成挑战。COVID-19 患者并发肝功能障碍和损伤相关的合并症的风险增加。此外,抗病毒治疗引起的肝毒性越来越受到重视,是一个令人十分关注的领域。目前,正在寻找减轻肝损伤的替代疗法,由于各种流行病学研究报告了它们在健康益处方面的多功能性,因此人们对生物活性植物化学物质(营养保健品)的研究兴趣日益浓厚。因此,本综述提供了相关信息,并总结了在 COVID-19 管理期间可能有用的抗病毒、免疫调节和保肝营养保健品的作用机制。