Yang Yiming, Zhai Xingjian, El Hiani Yassine
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, NS B3H 4R2, Canada.
Cells. 2020 Dec 13;9(12):2682. doi: 10.3390/cells9122682.
The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions.
黏脂质贮积蛋白-1（TRPML1）通道维持溶酶体离子稳态并调节自噬通量。TRPML1缺陷会导致溶酶体贮积病和神经退行性变。在本报告中，我们讨论了与TRPML1信号通路在癌症进展中的差异调节相关的新证据，目的是利用TRPML1的致癌潜力来启发治疗干预措施。
