Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, Poland.
Department of Hematology/Oncology, Clinic of Internal Medicine II, Jena University Hospital, 07747 Jena, Germany.
Cells. 2020 Dec 11;9(12):2660. doi: 10.3390/cells9122660.
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and differentiation. Vitamin A derivatives have held promise in cancer treatment and ATRA is used in differentiation therapy of acute promyelocytic leukemia (APL). ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, and ichthyosis. Moreover, modulation of retinoic acid receptors and retinoid X (or rexinoid) receptors function may affect dermal cells. The studies using complex genetic models with various combinations of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) indicate that retinoic acid and its derivatives have therapeutic potential for a variety of serious dermatological disorders including some malignant conditions. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology.
类视黄醇是一组化合物，包括维生素 A 和其活性代谢产物全反式视黄酸 (ATRA)。类视黄醇调节多种器官系统的多种生理功能，是正常免疫功能所必需的，并且参与细胞生长和分化的调节。维生素 A 衍生物在癌症治疗中具有广阔的前景，ATRA 用于急性早幼粒细胞白血病 (APL) 的分化治疗。ATRA 和其他类视黄醇也已成功应用于多种皮肤科疾病，如皮肤癌、银屑病、痤疮和鱼鳞病。此外，视黄酸受体和类视黄醇 X（或类视黄醇受体）功能的调节可能会影响皮肤细胞。使用具有各种组合的视黄酸受体 (RARs) 和类视黄醇 X（或类视黄醇受体）(RXRs) 的复杂遗传模型的研究表明，视黄酸及其衍生物对多种严重的皮肤病，包括某些恶性疾病具有治疗潜力。在这里，我们概述了理解 ATRA 及其受体在皮肤科中的作用的主要进展。
